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CAS No.: | 170842-80-5 |
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Name: | 3-BENZYL-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C20H29NO4 |
Molecular Weight: | 347.455 |
Synonyms: | 1-tert-Butyl 3-ethyl 3-benzylpiperidine-1,3-dicarboxylate;S-3-Carbethoxy-3-benzyl-N-Boc-piperidine;(+/-)-N-(t-butoxycarbonyl)-3-(carboethoxy)-3-(phenylmethyl)-piperidine;3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester; |
Density: | 1.101±0.06 g/cm3(Predicted) |
Boiling Point: | 431.8±38.0 °C(Predicted) |
PSA: | 55.84000 |
LogP: | 3.74740 |
ethyl N-(t-butyloxycarbonyl)nipecotate
benzyl bromide
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
Conditions | Yield |
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With lithium hexamethyldisilazane 1.) THF, -78 deg C, 2.) THF, from -78 deg C to 0 deg C; Multistep reaction; | |
With hydrogenchloride; sodium hexamethyldisilazane In tetrahydrofuran; ethyl acetate; toluene |
di-tert-butyl dicarbonate
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
Conditions | Yield |
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Multi-step reaction with 2 steps 1: CH2Cl2 2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to 0 deg C View Scheme |
Ethyl nipecotate
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
Conditions | Yield |
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Multi-step reaction with 2 steps 1: CH2Cl2 2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to 0 deg C View Scheme |
ethyl N-(t-butyloxycarbonyl)nipecotate
benzyl bromide
lithium diisopropyl amide
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
Conditions | Yield |
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In tetrahydrofuran |
phosphoric acid
boron trifluoride
tert-butyl nitrosoformate
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
Conditions | Yield |
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With triethylsilane; trifluoroborane diethyl ether In dichloromethane |
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
3-Benzyl-piperidine-3-carboxylic acid ethyl ester
Conditions | Yield |
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With hydrogenchloride In ethyl acetate |
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
Conditions | Yield |
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Multi-step reaction with 4 steps 1: HCl / ethyl acetate 3: HOBt, EDC / CH2Cl2 4: HCl / ethyl acetate View Scheme |
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
Conditions | Yield |
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Multi-step reaction with 6 steps 1: HCl / ethyl acetate 3: HOBt, EDC / CH2Cl2 4: HCl / ethyl acetate 5: HOBt, EDC / CH2Cl2 6: HCl / ethyl acetate View Scheme |
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
(S)-3-carbethoxy-3-benzylpiperidine
Conditions | Yield |
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Multi-step reaction with 2 steps 1: HCl / ethyl acetate View Scheme |
3-Benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester
(S)-3-Benzyl-1-[(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-piperidine-3-carboxylic acid ethyl ester
Conditions | Yield |
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Multi-step reaction with 3 steps 1: HCl / ethyl acetate 3: HOBt, EDC / CH2Cl2 View Scheme |