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CAS No.: | 1996-29-8 |
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Name: | 1-Bromo-4-chloro-2-fluorobenzene |
Molecular Structure: | |
Formula: | C6H3BrClF |
Molecular Weight: | 209.445 |
Synonyms: | 4-Bromo-1-chloro-3-fluorobenzene; |
Density: | 1.719 g/cm3 |
Boiling Point: | 187.3 °C at 760 mmHg |
Flash Point: | 67.1 °C |
Solubility: | insoluble in water |
Appearance: | CLEAR COLORLESS TO PALE YELLOW LIQUID |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 37/39-26 |
PSA: | 0.00000 |
LogP: | 3.24160 |
1-bromo-4-chloro-2-fluorobenzene
Conditions | Yield |
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(i) NaNO2, aq. HCl, (ii) HBF4, (iii) (thermolysis); Multistep reaction; |
2-fluoro-4-chloroaniline
1-bromo-4-chloro-2-fluorobenzene
Conditions | Yield |
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Stage #1: 2-fluoro-4-chloroaniline With hydrogen bromide; sodium nitrite In water at -10℃; for 0.5h; Stage #2: With hydrogen bromide; copper(I) bromide In water at -10 - 55℃; for 0.333333h; |
Conditions | Yield |
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With sodium bromide; copper(I) bromide; sodium sulfite; sodium nitrite In hydrogen bromide |
Conditions | Yield |
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With 18-crown-6 ether In dimethyl sulfoxide for 1h; Reflux; | 99% |
With sodium t-butanolate In N,N-dimethyl acetamide for 18h; Inert atmosphere; Heating; | 90% |
With 18-crown-6 ether; potassium fluoride on basic alumina In dimethyl sulfoxide for 8h; Inert atmosphere; Reflux; | 83% |
Ethyl isothiocyanate
1-bromo-4-chloro-2-fluorobenzene
4-chloro-N-ethyl-2-fluorobenzenecarbothioamide
Conditions | Yield |
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Stage #1: 1-bromo-4-chloro-2-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: Ethyl isothiocyanate In diethyl ether at -78℃; | 97% |
carbon monoxide
1-bromo-4-chloro-2-fluorobenzene
benzamidine monohydrochloride
7-chloro-5-methyl-2-phenylquinazolin-4(3H)-one
Conditions | Yield |
---|---|
With palladium diacetate; N-ethyl-N,N-diisopropylamine; catacxium A In N,N-dimethyl acetamide at 140℃; under 7500.75 Torr; for 22h; Inert atmosphere; Autoclave; | 97% |
tert-Butyl N-hydroxycarbamate
1-bromo-4-chloro-2-fluorobenzene
t-butyl N-(5-bromo-2-chlorophenoxy) carbamate
Conditions | Yield |
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With potassium hydroxide In dimethyl sulfoxide at 60℃; for 2h; | 96% |
1-bromo-4-chloro-2-fluorobenzene
(2-bromo-5-chlorophenyl)hydrazine
Conditions | Yield |
---|---|
With hydrazine hydrate In dimethyl sulfoxide at 70℃; for 72h; | 96% |
Conditions | Yield |
---|---|
With potassium phosphate In N,N-dimethyl-formamide at 150℃; | 93% |
1-bromo-4-chloro-2-fluorobenzene
Benzyl isothiocyanate
4-chloro-2-fluoro-N-(phenylmethyl)benzenecarbothioamide
Conditions | Yield |
---|---|
Stage #1: 1-bromo-4-chloro-2-fluorobenzene With n-butyllithium In tetrahydrofuran at -78℃; Stage #2: Benzyl isothiocyanate In diethyl ether at -78℃; | 92% |
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