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CAS No.: | 214701-49-2 |
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Name: | 1-(5-BROMO-PYRIDIN-2-YL)-ETHANONE |
Article Data: | 21 |
Molecular Structure: | |
Formula: | C7H6BrNO |
Molecular Weight: | 200.035 |
Synonyms: | 1-(5-Bromopyridin-2-yl)ethanone; |
EINECS: | 696-558-3 |
Density: | 1.534 g/cm3 |
Melting Point: | 112 °C |
Boiling Point: | 257.2 °C at 760 mmHg |
Flash Point: | 109.4 °C |
PSA: | 29.96000 |
LogP: | 2.04670 |
Conditions | Yield |
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With n-butyllithium In hexane; toluene at -40 - 20℃; for 2h; Inert atmosphere; | 100% |
Stage #1: 2,5-dibromopyridine With n-butyllithium In hexane; toluene at -40℃; for 0.666667h; Stage #2: N,N-dimethyl acetamide In hexane; toluene at 20℃; for 1h; Further stages.; | 83% |
Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene Inert atmosphere; Stage #2: N,N-dimethyl acetamide In toluene Inert atmosphere; | 83% |
N,N-dimethyl acetamide
2-iodo-5-bromopyridine
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
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Stage #1: 2-iodo-5-bromopyridine With n-butyllithium In hexane; toluene at -40℃; for 1h; Stage #2: N,N-dimethyl acetamide In hexane; toluene at -40 - 20℃; for 1h; | 91% |
5-bromo-N-methyoxy-N-methylpyridine-2-carboxamide
methylmagnesium chloride
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
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In tetrahydrofuran at 0 - 20℃; for 1h; | 90% |
3-bromo-6-(trimethylsilylethynyl)pyridine
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
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With sulfuric acid; mercury(II) diacetate In water; acetone for 1h; Heating; | 80% |
methylmagnesium bromide
2-Cyano-5-bromopyridine
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
---|---|
Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - -10℃; for 3h; Stage #2: With hydrogenchloride In tetrahydrofuran at -35℃; for 0.166667h; Further stages.; | 65% |
Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - -10℃; for 3h; Stage #2: With hydrogenchloride; water In tetrahydrofuran at -40 - -35℃; for 0.166667h; | 65% |
Stage #1: methylmagnesium bromide; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20 - -10℃; for 3h; Stage #2: With hydrogenchloride; water In tetrahydrofuran at -40 - -35℃; for 0.166667h; Stage #3: In tetrahydrofuran; water pH=7; potassium phosphate buffer; | 65% |
2,5-dibromopyridine
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 65 percent / NaCN / dimethylformamide / 3 h / Heating 2: tetrahydrofuran / 2 h / -20 °C View Scheme |
methylmagnesium chloride
2-Cyano-5-bromopyridine
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
---|---|
Stage #1: methylmagnesium chloride; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20℃; for 2h; Stage #2: With water; ammonium chloride In tetrahydrofuran | |
Stage #1: methylmagnesium chloride; 2-Cyano-5-bromopyridine In tetrahydrofuran at -20℃; for 2h; Stage #2: With water; ammonium chloride In tetrahydrofuran |
5-bromoisonicotinic acid
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
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Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 18 - 25 °C 2: tetrahydrofuran / 1 h / -78 °C View Scheme | |
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C 2: tetrahydrofuran / 1 h / 0 - 20 °C View Scheme |
5-bromo-2-(N-methylaminocarbonyl)pyridine
methyllithium
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
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In tetrahydrofuran at -78℃; for 1h; |
2-iodo-5-bromopyridine
1-(5-bromopyridin-2-yl)ethanone
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: isopropylmagnesium bromide / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice 1.2: 0.5 h / 20 °C / Cooling with ice 2.1: manganese(IV) oxide / dichloromethane / 40 °C View Scheme |
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Empirical Formula: C7H6BrNO
Molecular Weight: 200.0326
Nominal Mass: 199 Da
Average Mass: 200.0326 Da
Monoisotopic Mass: 198.963269 Da
Index of Refraction: 1.558
Molar Refractivity: 42.06 cm3
Molar Volume: 130.3 cm3
Surface Tension: 44.6 dyne/cm
Density: 1.534 g/cm3
Flash Point: 109.4 °C
Enthalpy of Vaporization: 49.48 kJ/mol
Boiling Point: 257.2 °C at 760 mmHg
Vapour Pressure: 0.0147 mmHg at 25 °C
Structure of 2-Acetyl-5-bromopyridine (CAS NO.214701-49-2):
Product Category of 2-Acetyl-5-bromopyridine (CAS NO.214701-49-2): API intermediates;Pyridines
2-Acetyl-5-bromopyridine , its cas register number is 214701-49-2. It also can be called 1-(5-Brom-2-pyridinyl)ethanon ; 1-(5-Bromo-2-pyridinyl)ethanone ; and 5-Bromo-2-acetylpyridine .