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22260-42-0

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Basic Information
CAS No.: 22260-42-0
Name: curarine
Molecular Structure:
Molecular Structure of 22260-42-0 (curarine)
Formula: C38H44 N2 O6
Molecular Weight: 624.84
Synonyms: Bebeerinium,2,2'-dimethyl- (8CI);Curarine (7CI);Tubocuraranium,7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'a)-;(+)-2,2'-Dimethylbebeerine;(+)-Curarine;13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium,2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,1,14,14-tetramethyl-,[13aS-(13aR*,25aR*)]-;Bebeerine, 2,2'-dimethyl-, (+)-;Curarine (C38alkaloid);Curarine (C38 alkaloid), (+)-;N,N'-Dimethylbebeerinium;
EINECS: 244-880-6
Hazard Symbols: 3
Safety: A deadly poison by ingestion, subcutaneous, intramuscular and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
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Chemistry

Product Name: Curarine
Synonyms of Curarine (CAS NO.22260-42-0) : (+)-2,2'-Dimethylbebeerine ; (+)-Curarine ; Curarine (C38 alkaloid), (+)- ; N,N'-Dimethylbebeerinium ; Tubocuraranium, 7',12'-dihydroxy-6,6'-dimethoxy-2,2,2',2'-tetramethyl-, (1'alpha)- ;13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium, 2,3,13a,14,15,16,25,25a-octahydro-9,19-dihydroxy-18,29-dimethoxy-1,1,14,14-tetramethyl-, (13aS,25aS)-
Classification Code :Drug / Therapeutic Agent ;Natural Product
CAS NO:22260-42-0
Molecular Formula:C38H44N2O6
Molecular Weight :624.7647
Molecular Structure :
EINECS: 244-880-6

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 340ug/kg (0.34mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog LDLo subcutaneous 340ug/kg (0.34mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog LDLo subcutaneous 16800ug/kg (16.8mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
frog LDLo unreported 8400ug/kg (8.4mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 637, 1948.
guinea pig LDLo subcutaneous 90ug/kg (0.09mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse LDLo subcutaneous 380ug/kg (0.38mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
pigeon LDLo intramuscular 618ug/kg (0.618mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
pigeon LDLo subcutaneous 618ug/kg (0.618mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LDLo intravenous 80ug/kg (0.08mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit LDLo oral 334mg/kg (334mg/kg)   Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 61, Pg. 283, 1909.
rabbit LDLo subcutaneous 340ug/kg (0.34mg/kg)   "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 633, 1948.

Safety Profile

A deadly poison by ingestion, subcutaneous, intramuscular and intravenous routes. When Curarine (CAS NO.22260-42-0)  is heated to decomposition, it emits toxic fumes of NOx.