CAS No.224785-90-4,Vardenafil hydrochloride trihydrate Suppliers

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Basic Information

Molecular Structure:
CAS No.:	224785-90-4
Name:	Vardenafil hydrochloride trihydrate
Article Data:	12

Formula:	C₂₃H₃₂N₆O₄S
Molecular Weight:	488.611
Synonyms:	Piperazine,1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-(9CI);2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one;Nuviva;BAY 38-9456;1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine;Vivanza;
EINECS:	200-835-2
Density:	1.37 g/cm³
Melting Point:	230-235 °C
Boiling Point:	692.2 °C at 760 mmHg
Flash Point:	372.5 °C
Solubility:	Soluble in water and alcohol
Appearance:	White crystalline powder
Hazard Symbols:	F,Xn
Risk Codes:	11-20/21/22-36
Safety:	16-36/37
PSA:	121.28000
LogP:	4.63100

Synthetic route

: 5308-25-8
4-ethylpiperazine

: 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 224785-90-4
vardenafil

Conditions

Conditions	Yield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at 0 - 22℃; for 0.75h; Stage #2: 4-ethylpiperazine In dichloromethane at -3 - 25℃; for 0.75h; Product distribution / selectivity;

: 5308-25-8
4-ethylpiperazine

: 224789-26-8
4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

: 224785-90-4
vardenafil

Conditions

Conditions	Yield
In dichloromethane

: 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 224785-90-4
vardenafil

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chlorosulfonic acid / dichloromethane / 24 h / 23 - 90 °C 2: dichloromethane View Scheme

: 5308-25-8
4-ethylpiperazine

: 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 224785-90-4
vardenafil

Conditions

Conditions	Yield
Stage #1: 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one With chlorosulfonic acid at 0 - 22℃; for 0.75h; Stage #2: 4-ethylpiperazine In dichloromethane at -3 - 25℃; for 0.75h; Product distribution / selectivity;

: 224789-21-3
2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

: 224785-90-4
vardenafil

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chlorosulfonic acid / dichloromethane / 24 h / 23 - 90 °C 2: dichloromethane View Scheme

: 5308-25-8
4-ethylpiperazine

: 224789-26-8
4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenelsulfonic acid chloride

: 224785-90-4
vardenafil

Conditions

Conditions	Yield
In dichloromethane

: 224785-90-4
vardenafil

: vardenafil hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water; acetone at 50℃; Solvent; Temperature; pH-value; Reagent/catalyst;	77%

: 224785-90-4
vardenafil

: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride dihydrate

Conditions

Conditions	Yield
With hydrogenchloride; water In acetone at 29 - 55℃; for 0.5h;

: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride dihydrate

: 224785-90-4
vardenafil

: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride monohydrate

Conditions

Conditions	Yield
Stage #1: vardenafil With water In acetone at 28℃; for 0.166667h; Stage #2: With hydrogenchloride; water In acetone at 5 - 55℃; for 0.5h; Stage #3: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride dihydrate In acetone at 3℃;

: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride dihydrate

: 224785-90-4
vardenafil

: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride trihydrate

Conditions

Conditions	Yield
Stage #1: vardenafil With hydrogenchloride; water In acetone at 5 - 56℃; for 0.5h; Stage #2: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethylpiperazine dihydrochloride dihydrate In acetone at 3℃;

Raw Materials

224789-21-3

224789-26-8

5308-25-8

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Chemistry

IUPAC Name: 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one
Synonyms of Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4): 1-((3-(3,4-Dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine ; 2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one ; BAY 38-9456 ; BAY38-9456 ; HSDB 7304 ; Levitra ; UNII-UCE6F4125H ; Vivanza ; Piperazine, 1-((3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo(5,1-f)(1,2,4)triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethyl-
CAS NO: 224785-90-4
Classification Code: Enzyme Inhibitors ; Phosphodiesterase 5 Inhibitors ; Phosphodiesterase Inhibitors
Molecular Formula of Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4): C₂₃H₃₂N₆O₄S
Molecular Weight: 488.603
Molecular Structure:

Melting Point: 214-216°C
Polar Surface Area: 108.72 Å²
Index of Refraction: 1.656
Molar Refractivity: 130.63 cm³
Molar Volume: 355.4 cm³
Surface Tension: 53.3 dyne/cm
Density of Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4): 1.37 g/cm³
Flash Point: 372.5 °C
Enthalpy of Vaporization: 101.43 kJ/mol
Boiling Point: 692.2 °C at 760 mmHg
Vapour Pressure: 5.17E-19 mmHg at 25°C

Uses

Vardenafil hydrochloride trihydrate (CAS NO.224785-90-4) is used as a selective phsphodiesterase type 5 (PDE5) inhibitor.