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CAS No.: | 25519-80-6 |
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Name: | 4-BENZOYLPIPERIDINE HYDROCHLORIDE |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C12H15 N O . Cl H |
Molecular Weight: | 225.718 |
Synonyms: | Ketone,phenyl 4-piperidyl, hydrochloride (8CI); Methanone, phenyl-4-piperidinyl-,hydrochloride (9CI); 4-Benzoylpiperidine hydrochloride;Phenyl(piperidin-4-yl)methanone hydrochloride |
Density: | g/cm3 |
Melting Point: | 95-97oC |
Boiling Point: | 310.7°Cat760mmHg |
Flash Point: | 125.3°C |
Hazard Symbols: | Xi |
PSA: | 29.10000 |
LogP: | 2.99970 |
1-(t-butoxycarbonyl)-4-(benzoyl)piperidine
4-(benzoyl)piperidine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane at 18 - 25℃; for 0.5h; | 98% |
With hydrogenchloride In 1,4-dioxane |
1-(4-benzoylpiperidin-1-yl)ethanone
4-(benzoyl)piperidine hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran for 10h; Reflux; |
1-acetyl-piperidine-4-carboxylic acid
4-(benzoyl)piperidine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4 h / 0 - 60 °C 2: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 65 °C 3: hydrogenchloride; water / tetrahydrofuran / 10 h / Reflux View Scheme |
isonipecotic acid
4-(benzoyl)piperidine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: pyridine / 2 h / 140 °C 2: thionyl chloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 4 h / 0 - 60 °C 3: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 65 °C 4: hydrogenchloride; water / tetrahydrofuran / 10 h / Reflux View Scheme |
1-acetylpiperidine-4-carbonyl chloride
4-(benzoyl)piperidine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 65 °C 2: hydrogenchloride; water / tetrahydrofuran / 10 h / Reflux View Scheme |
benzyl chloroformate
4-(benzoyl)piperidine hydrochloride
4-benzoylpiperidine-1-carboxylic acid benzyl ester
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran at 0 - 20℃; for 2h; | 100% |
With potassium carbonate In tetrahydrofuran at 0 - 25℃; for 15h; Inert atmosphere; | 97.76% |
With potassium carbonate In tetrahydrofuran at 0 - 20℃; for 2h; | 90% |
With potassium carbonate In 1,4-dioxane; water Cooling with ice; | 1.43 g |
di-tert-butyl dicarbonate
4-(benzoyl)piperidine hydrochloride
1-(t-butoxycarbonyl)-4-(benzoyl)piperidine
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; water for 1h; Condensation; Heating; | 98% |
With sodium carbonate In tetrahydrofuran; water for 1h; Heating; | 98% |
With potassium hydrogencarbonate In H2 O-TBF | 98% |
4-(benzoyl)piperidine hydrochloride
1-methyl-1H-imidazole-4-sulfonyl chloride
(1-(1-Methyl-1H-Imidazol-4-ylsulfonyl)Piperidin-4-yl)(Phenyl)Methanone
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane for 18h; | 93% |
2-(benzylthio)-4-(4-methoxyphenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
4-(benzoyl)piperidine hydrochloride
C31H28N4O2S
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 12h; | 70% |
4-(benzoyl)piperidine hydrochloride
C30H25ClN4OS
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 12h; | 64% |