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CAS No.: | 25905-77-5 |
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Name: | MINAPRINE DIHYDROCHLORIDE |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C17H22 N4 O |
Molecular Weight: | 298.388 |
Synonyms: | Minaprine;Mineprine |
Density: | 1.156g/cm3 |
Melting Point: | 122° |
Boiling Point: | 531.2°C at 760 mmHg |
Flash Point: | 275.1°C |
Hazard Symbols: | Xn |
Risk Codes: | 22 |
PSA: | 50.28000 |
LogP: | 3.81100 |
4-(2-AMINOETHYL)MORPHOLINE
3-chloro-4-methyl-6-phenylpyridazine
4-(2-aminoethyl)morpholine hydrochloride
minaprine
Conditions | Yield |
---|---|
at 170℃; for 2h; | 69% |
3-methoxy-6-phenylpyridazine
minaprine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 1.) n-butyllithium, 2,2,6,6-tetramethylpiperidine / 1.) hexane, 0 degC, 30 min, THF, -70 degC, 1.5 h; 2.) -70 degC, 2 h 2: 96 percent / 57percent hydroiodic acid / 5 h / 80 °C 3: 94 percent / phopsphorus oxychloride / 6 h / 90 °C 4: 69 percent / 2 h / 170 °C View Scheme |
4-methyl-6-phenylpyridazin-3(2H)-one
minaprine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / phopsphorus oxychloride / 6 h / 90 °C 2: 69 percent / 2 h / 170 °C View Scheme |
3-methoxy-4-methyl-6-phenylpyridazine
minaprine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 96 percent / 57percent hydroiodic acid / 5 h / 80 °C 2: 94 percent / phopsphorus oxychloride / 6 h / 90 °C 3: 69 percent / 2 h / 170 °C View Scheme |
phenylboronic acid
minaprine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 75 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol / 12 h / Heating 2: 1.) n-butyllithium, 2,2,6,6-tetramethylpiperidine / 1.) hexane, 0 degC, 30 min, THF, -70 degC, 1.5 h; 2.) -70 degC, 2 h 3: 96 percent / 57percent hydroiodic acid / 5 h / 80 °C 4: 94 percent / phopsphorus oxychloride / 6 h / 90 °C 5: 69 percent / 2 h / 170 °C View Scheme |