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Basic Information
| CAS No.: | 2730-71-4 |
|---|---|
| Name: | thiocolchicine |
| Article Data: | 20 |
| Molecular Structure: | |
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| Formula: | C22H25 N O5 S |
| Molecular Weight: | 415.51 |
| Synonyms: | Acetamide,N-[5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-,(S)-; Colchicine, 10-thio- (8CI); Colchicine, thio- (6CI); Benzo[a]heptalene,acetamide deriv.; 10-Demethoxy-10-(methylthio)colchicine; NSC 186301;Thiocolchicine |
| Density: | 1.27g/cm3 |
| Melting Point: | 193℃ |
| Boiling Point: | 729.1°Cat760mmHg |
| Flash Point: | 394.7°C |
| Hazard Symbols: | Xi |
| Risk Codes: | 36/37/38 |
| PSA: | 99.16000 |
| LogP: | 3.97580 |
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Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| In water for 1h; Heating; | 95% |
| In methanol; water at 20℃; for 72h; | 78% |
| In methanol; water at 20℃; for 72h; | 78% |
Conditions
| Conditions | Yield |
|---|---|
| With pyridine for 4h; Ambient temperature; | 93.5% |
Conditions
| Conditions | Yield |
|---|---|
| With methylthiol; toluene-4-sulfonic acid at -80 - -20℃; | 80% |
Conditions
| Conditions | Yield |
|---|---|
| With zinc(II) chloride | |
| With toluene-4-sulfonic acid |
- 186581-53-3, 908094-01-9
diazomethane
- 2730-71-4
thiocolchicine
- 209810-38-8
N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide
- 2730-71-4
thiocolchicine
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 71 percent / methanol; dimethylformamide / Ambient temperature 2: 89 percent / 2N aq. HCl / methanol / 60 h / 85 - 90 °C 3: 22 percent / pyridine / Ambient temperature 4: 10 percent / 20percent methanol. HCl / 72 h / 90 °C 5: 93.5 percent / pyridine / 4 h / Ambient temperature View Scheme |
- 2731-16-0
7-amino-1,2,3-trimethoxy-10-methylsulfanyl-6,7-dihydro-5H-benzo[a]-heptalen-9-one
- 2730-71-4
thiocolchicine
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 22 percent / pyridine / Ambient temperature 2: 10 percent / 20percent methanol. HCl / 72 h / 90 °C 3: 93.5 percent / pyridine / 4 h / Ambient temperature View Scheme |
- 209810-39-9, 181711-09-1
thiocolchicine
- 2730-71-4
thiocolchicine
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 89 percent / 2N aq. HCl / methanol / 60 h / 85 - 90 °C 2: 22 percent / pyridine / Ambient temperature 3: 10 percent / 20percent methanol. HCl / 72 h / 90 °C 4: 93.5 percent / pyridine / 4 h / Ambient temperature View Scheme |
- 203584-67-2
(1S,4R)-4,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-1-carboxylic acid ((S)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-amide
- 2730-71-4
thiocolchicine
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 10 percent / 20percent methanol. HCl / 72 h / 90 °C 2: 93.5 percent / pyridine / 4 h / Ambient temperature View Scheme |
- 2730-71-4
thiocolchicine
- 2826-75-7
N-<5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxo-10-(methylsulfonyl)benzoheptalen-7-yl>-(S)-acetamide
Conditions
| Conditions | Yield |
|---|---|
| With 3-chloro-benzenecarboperoxoic acid In chloroform at 0 - 5℃; for 22h; | 100% |
Downstream Products
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