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2970-95-8

Basic Information
CAS No.: 2970-95-8
Name: 1-(3,4-Dimethoxy-phenyl)-2-dimethylamino-ethanol
Article Data: 8
Molecular Structure:
Molecular Structure of 2970-95-8 (1-(3,4-Dimethoxy-phenyl)-2-dimethylamino-ethanol)
Formula: C12H19 N O3
Molecular Weight: 225.288
Synonyms: Veratrylalcohol, a-[(dimethylamino)methyl]-(6CI,7CI,8CI); (?à)-Macromerine;3,4-Dimethoxy-N-methylepinephrine; Macromerine; dl-Macromerine
Density: 1.079g/cm3
Melting Point: 66.0-67.5 °C
Boiling Point: 348.1°Cat760mmHg
Flash Point: 164.3°C
PSA: 41.93000
LogP: 1.29880
Synthetic route
127901-47-7

N,N-dimethyl-3,4-dimethoxyphenylglyoxamide

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 1h; Heating;88%
33061-24-4

1-(3,4-dimethoxyphenyl)-2-(dimethylamino)ethanone

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 20℃; for 3.25h;80%
33061-25-5

1-(3,4-dimethoxyphenyl)-2-(dimethylamino)ethanone hydrochloride

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
With ethanol; platinum Hydrogenation;
91-16-7

1,2-dimethoxybenzene

3976-11-2

N,N-dimethyl-glycine nitrile; hydrochloride

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
(i), (ii) NaBH4; Multistep reaction;
26285-62-1

dimethylaminomethyltributyltin

120-14-9

3,4-dimethoxy-benzaldehyde

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
With n-butyllithium 1.) hexane, THF, -78 deg C, 15 min, 2.) -78 deg C, 2 h; Yield given. Multistep reaction;
91-16-7

1,2-dimethoxybenzene

ClO2

ClO2

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 42 percent / p-toluenesulfonic acid / 1,2-dichloro-ethane / 1 h / Heating
2: sodium metaperiodate / H2O; methanol / 15 h / Ambient temperature
3: acetic anhydride / 0.5 h / Heating
4: 88 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
View Scheme
127901-45-5

2-(3,4-Dimethoxy-phenyl)-2-methanesulfinyl-N,N-dimethyl-acetamide

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic anhydride / 0.5 h / Heating
2: 88 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
View Scheme
127901-39-7

2-(3,4-Dimethoxy-phenyl)-N,N-dimethyl-2-methylsulfanyl-acetamide

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium metaperiodate / H2O; methanol / 15 h / Ambient temperature
2: acetic anhydride / 0.5 h / Heating
3: 88 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
View Scheme
90-05-1

2-methoxy-phenol

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 55 °C
2.1: aluminum (III) chloride / dichloromethane / 0.58 h / -5 - 0 °C
2.2: 1 h / -5 - 0 °C
3.1: bromine / chloroform / 3 h / 20 °C
4.1: ethanol / 0.67 h / 0 - 5 °C
5.1: sodium tetrahydroborate / methanol / 3.25 h / 20 °C
View Scheme
91-16-7

1,2-dimethoxybenzene

2970-95-8

1-(3, 4-dimethoxyphenyl)-2-dimethylaminoethanol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: aluminum (III) chloride / dichloromethane / 0.58 h / -5 - 0 °C
1.2: 1 h / -5 - 0 °C
2.1: bromine / chloroform / 3 h / 20 °C
3.1: ethanol / 0.67 h / 0 - 5 °C
4.1: sodium tetrahydroborate / methanol / 3.25 h / 20 °C
View Scheme
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