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| CAS No.: | 300543-56-0 |
|---|---|
| Name: | (-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine |
| Article Data: | 10 |
| Molecular Structure: | |
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|
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| Formula: | C17H19 Cl N2 |
| Molecular Weight: | 286.804 |
| Synonyms: | (-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine;(R)-1-(p-Chlorobenzhydryl)piperazine |
| Density: | 1.158 |
| Melting Point: | 91-93oC |
| Boiling Point: | 409.1oC at 760 mmHg |
| Flash Point: | 193.3oC |
| Solubility: | Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water. |
| PSA: | 15.27000 |
| LogP: | 3.60130 |
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- 1161573-31-4
(R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine N-acetyl-L-phenylalanine salt
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water at 20℃; for 12.5h; Product distribution / selectivity; | 99% |
| With sodium hydroxide; water In ethyl acetate Product distribution / selectivity; | 90% |
- 943987-59-5
(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| Stage #1: (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methoxyphenyl)sulfonyl]piperazine With hydrogen bromide; acetic acid at 70 - 75℃; for 3h; Industry scale; Stage #2: With sodium hydroxide In water at 0 - 35℃; pH=~ 12 - ~ 14; Product distribution / selectivity; Industry scale; | 92.7% |
- 942283-97-8
(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| Stage #1: (-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine With hydrogen bromide; acetic acid; 4-hydroxy-benzoic acid at 25℃; for 17h; Stage #2: With sodium hydroxide In water Product distribution / selectivity; | 84.8% |
- 821-48-7
bis-(2-chloroethyl)amine hydrochloride
- 163837-57-8
(R)-(4-chlorophenyl)(phenyl)methylamine
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| Stage #1: bis-(2-chloroethyl)amine hydrochloride; (R)-(4-chlorophenyl)(phenyl)methylamine With N-ethyl-N,N-diisopropylamine for 3h; Heating / reflux; Stage #2: With diethylamine at 60℃; for 5h; Heating / reflux; Stage #3: With sodium hydroxide; water pH=10 - 11; | |
| Stage #1: bis-(2-chloroethyl)amine hydrochloride; (R)-(4-chlorophenyl)(phenyl)methylamine With N-ethyl-N,N-diisopropylamine for 3h; Reflux; Stage #2: With diethylamine at 60℃; Reflux; |
- 941576-99-4
(R)-(+)-4-(4-chlorophenyl)-phenylmethyl-piperazine-1-carboxylic acid-2,2,2-trichloroethylester
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water In isopropyl alcohol at 20 - 100℃; Product distribution / selectivity; |
- 1136010-90-6
C24H23ClN2O2
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water In isopropyl alcohol for 3 - 3.5h; Product distribution / selectivity; Heating / reflux; | n/a |
- 1155402-57-5
C25H25ClN2O2
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water In isopropyl alcohol for 1.5h; Product distribution / selectivity; Heating / reflux; |
- 1155402-66-6
C25H25ClN2O3
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water In isopropyl alcohol for 2.75h; Product distribution / selectivity; Heating / reflux; |
- 1155402-68-8
C24H22ClN3O4
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water In isopropyl alcohol at 50℃; for 3.5h; Product distribution / selectivity; |
- 1136010-92-8
C25H25ClN2O2
- 300543-56-0
(R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide; water In isopropyl alcohol at 100℃; for 5h; Product distribution / selectivity; |
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Chemistry
Systematic Name: 1-[(4-Chlorophenyl)(phenyl)methyl]piperazine
Synonyms of (-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine (CAS NO.300543-56-0): (R)-1-(p-Chlorobenzhydryl)piperazine
CAS NO: 300543-56-0
Molecular Formula: C17H19ClN2
Molecular Weight: 286.80
Molecular Structure: 
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 6.48Å2
Index of Refraction: 1.592
Molar Refractivity: 83.82 cm3
Molar Volume: 247.6 cm3
Surface Tension: 44 dyne/cm
Density: 1.158 g/cm3
Flash Point: 193.3 °C
Enthalpy of Vaporization: 66.12 kJ/mol
Boiling Point: 409.1 °C at 760 mmHg
Vapour Pressure: 6.66E-07 mmHg at 25°C
SMILES: Clc1ccc(cc1)C(c2ccccc2)N3CCNCC3
InChI: InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2
InChIKey: UZKBSZSTDQSMDR-UHFFFAOYAS
Std. InChI: InChI=1S/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2
Std. InChIKey: UZKBSZSTDQSMDR-UHFFFAOYSA-N