CAS No.3200-06-4,alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	3200-06-4
Name:	alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
Article Data:	2

Formula:	C₂₄H₃₃NO₃^.C₂H₂O₄
Molecular Weight:	473.566
Synonyms:	Naftidrofuryl oxalate; alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
EINECS:	221-703-0
Density:	1.2205 (rough estimate)
Melting Point:	110-111°
Boiling Point:	664.4°C at 760 mmHg
Flash Point:	355.6°C
Hazard Symbols:
Risk Codes:	R22
Safety:	Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	113.37000
LogP:	3.60820

Synthetic route

: 31329-57-4, 47583-18-6
nafronyl

: 144-62-7
oxalic acid

: 3200-06-4
Gevatran

Conditions

Conditions	Yield
In water; acetone for 1h; Reflux;	80%

Raw Materials

144-62-7

86-52-2

25379-26-4

97-99-4

31329-57-4

Total:78 Page 1 of 3 1 2 3 Next>>

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Chemistry

Product Name: Nafronyl oxalate (CAS NO.3200-06-4)

Molecular Formula: C₂₆H₃₅NO₇
Molecular Weight: 473.56g/mol
Mol File: 221-703-0.mol
H-Bond Donor: 2
H-Bond Acceptor: 8
Structure Descriptors of Nafronyl oxalate (CAS NO.3200-06-4):
IUPAC Name: 2-diethylaminoethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate;oxalic acid
Canonical SMILES: CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=CC=CC3=CC=CC=C32.C(=O)(C(=O)O)O
InChI: InChI=1S/C24H33NO3.C2H2O4/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20;3-1(4)2(5)6/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3;(H,3,4)(H,5,6)
InChIKey: SSAJNPNVUYMUCI-UHFFFAOYSA-N

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	intravenous	71mg/kg (71mg/kg)		Chimica Therapeutica. Vol. 3, Pg. 463, 1968.
mouse	LD50	intramuscular	696mg/kg (696mg/kg)		Chimica Therapeutica. Vol. 3, Pg. 463, 1968.
mouse	LD50	intraperitoneal	159mg/kg (159mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
mouse	LD50	intravenous	18400ug/kg (18.4mg/kg)		United States Patent Document. Vol. #4439442,
mouse	LD50	oral	365mg/kg (365mg/kg)		United States Patent Document. Vol. #4652583,
mouse	LD50	subcutaneous	547mg/kg (547mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
rabbit	LDLo	intravenous	8mg/kg (8mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 11, Pg. 103, 1985.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)	GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH	Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. Vol. 11, Pg. 81, 1985.
rat	LD50	intraperitoneal	98mg/kg (98mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
rat	LD50	intravenous	11080ug/kg (11.08mg/kg)		United States Patent Document. Vol. #4439442,
rat	LD50	oral	711mg/kg (711mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.
rat	LD50	subcutaneous	896mg/kg (896mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14, Pg. 1237, 1986.

Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of Nafronyl oxalate (CAS NO.3200-06-4):
Hazard Codes: Xn Harmful ,Xi Irritant
Risk Statements: 22
22: Harmful if swallowed
Safety Statements: 36
36: Wear suitable protective clothing .

Specification

Nafronyl oxalate ,its CAS NO. is 3200-06-4,the synonyms is Diethyl(2-(2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy)ethyl)ammonium hydrogen oxalate ; 2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate oxalate (1:1) ; Dubimax ; Dusodril ; EINECS 221-703-0 ; EU-1806 ; Gevatran ; Iridus ; LS 121 ; NSC 225233 ; Naftidrofuryl oxalate ; Naphtidrofuryl oxalate ; Praxilene ; UNII-5ADB8D9388 .