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CAS No.: | 3973-08-8 |
---|---|
Name: | 4-Thiazolecarboxylic acid |
Article Data: | 25 |
Molecular Structure: | |
Formula: | C4H3NO2S |
Molecular Weight: | 129.139 |
Synonyms: | 1,3-Thiazole-4-carboxylicacid;NSC 195467; |
EINECS: | 628-056-7 |
Density: | 1.525 g/cm3 |
Melting Point: | 195-199 °C(lit.) |
Boiling Point: | 319.2 °C at 760 mmHg |
Flash Point: | 146.9 °C |
Hazard Symbols: | Xi |
Risk Codes: | 43 |
Safety: | 36/37 |
PSA: | 78.43000 |
LogP: | 0.84130 |
4-thiazolecarboxylate methyl ester
Thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide for 1h; Reflux; | 96.1% |
Conditions | Yield |
---|---|
Stage #1: ethyl Bromopyruvate; thiourea In water at 40℃; for 5h; Stage #2: With hydrogenchloride; sodium nitrite In water for 2h; Temperature; Concentration; | 94% |
Conditions | Yield |
---|---|
at 30℃; for 16h; Pseudomonas putida ATCC 33015; | 80% |
With potassium permanganate In water at 55℃; for 22h; Reagent/catalyst; Temperature; | 70.2% |
bromopyruvic acid
formamide
Thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: formamide With tetraphosphorus decasulfide In tetrahydrofuran at 30℃; for 3h; Stage #2: bromopyruvic acid In tetrahydrofuran at 40 - 50℃; for 3h; | 22% |
1,2,3,4-tetrahydroisoquinoline
thiazole 2,5-dicarboxylic acid
Thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
at 153.9℃; Rate constant; sowie bei 164.7.Decarboxylation; |
ethyl 2-bromothiazole-4-carboxylate
Thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
With potassium hydroxide anschliessend Hydrieren an Raney-Nickel; |
2-propionyl-thiazole-4-carboxylic acid
Thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid at 180℃; |
2-propionyl-thiazole-4-carboxylic acid
A
Thiazole-4-carboxylic acid
B
thiazole-2,4-dicarboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide; potassium permanganate |
thiazole-2,4-dicarboxylic acid
Thiazole-4-carboxylic acid
Conditions | Yield |
---|---|
at 140 - 144℃; Decarboxylation; |
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IUPAC Name: 1,3-thiazole-4-carboxylic acid (3973-08-8)
Synonyms: 1,3-Thiazole-4-carboxylic acid ; Akos bb-9161 ; 4-Carboxythiazole ; 4-Thiazolecarboxylic acid ; Timtec-bb sbb010166 ; Thiazole-4-carboxylic acid ; 4-Thiazolecarboxylic acid 3973-8-8 ; 1,3-Thiazole-4-carboxylic acid 3973-8-8
CAS: 3973-08-8
MF: C4H3NO2S
MW: 129.14
MS:
Product Categories: blocks ; Carboxes ; Thiazoles ; Sulphur Derivatives ; Carboxylic Acids ; Thiazoles, Isothiazoles &Benzothiazoles ; Carboxylic Acids ; Thiazoles, Isothiazoles & Benzothiazoles ; Building Blocks ; Heterocyclic Building Blocks
Mol File: 3973-08-8.mol
Surface Tension: 72 dyne/cm Density: 1.525 g/cm3
Flash Point: 146.9 °C Enthalpy of Vaporization: 59.21 kJ/mol
Boiling Point: 319.2 °C at 760 mmHg Vapour Pressure: 0.000143 mmHg at 25°C
MP:195-199 °C(lit.)
1.4-Thiazolecarboxylic acid (93973-08-8) is an intermediate of fungicide thiabendazole.
2.4-Thiazolecarboxylic acid (93973-08-8) is used as a medicine, pesticide intermediates, organic synthesis reagents .
Its preparation method is to use formamide with P2S5 in ethylene glycol dimethyl ether (CH3OCH2CH2OCH3) reaction to obtain thiocarboxamide (HCSNH2), and then, halogenate with pyruvate for product.
Hazard Codes: Xi
Risk Statements: 43
43: 4-Thiazolecarboxylic acid (93973-08-8) may cause sensitization by skin contact
Safety Statements : 36/37
36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
4-Thiazolecarboxylic acid (93973-08-8) is a colorless solid, not dissolve in water.