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CAS No.: | 40615-39-2 |
---|---|
Name: | 5'-O-Dimethoxytrityl-deoxythymidine |
Article Data: | 163 |
Molecular Structure: | |
Formula: | C31H32N2O7 |
Molecular Weight: | 544.604 |
Synonyms: | Thymidine,5'-O-[a,a-bis(p-methoxyphenyl)benzyl]- (7CI);5'-O-(4,4'-Dimethoxytrityl)-2'-deoxythymidine;5'-O-(4,4'-Dimethoxytrityl)thymidine;5'-O-(Di-p-methoxytrityl)thymidine;5'-O-(p,p'-Dimethoxytrityl)thymidine; |
EINECS: | 255-003-1 |
Density: | 1.272 g/cm3 |
Melting Point: | 114-116 °C (subl.)(lit.) |
Boiling Point: | 618.41°C (rough estimate) |
Solubility: | 3mg/L at 20℃ |
Appearance: | White powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36 |
PSA: | 112.01000 |
LogP: | 3.51930 |
4,4'-dimethoxytrityl chloride
thymidine
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
With pyridine; dmap at 20℃; for 5h; | 97% |
With pyridine; dmap at 20℃; for 24h; | 96% |
With pyridine at 20℃; for 12h; | 96% |
2-Azidomethyl-benzoic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
With diphenyl(methyl)phosphine In 1,4-dioxane; water at 20℃; for 0.25h; Product distribution; Further Variations:; Catalysts; Reaction partners; Reagents; Solvents; reaction times; | 96% |
thymidine
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-4-methylpyridine In nitromethane at 20℃; for 17h; or pyridine, other solvents; | 93% |
With lithium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Heating; | 74% |
4,4'-dimethoxytrityl chloride
thymidine
A
5'-O-(4-4'-dimethoxytrityl)thymidine
B
3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine
Conditions | Yield |
---|---|
With pyridine at 20℃; for 1.5h; | A 93% B n/a |
With pyridine at 20℃; for 1.5h; | A 93% B n/a |
With pyridine at 20℃; for 1.5h; | A 93% B n/a |
pyridine
4,4'-dimethoxytrityl chloride
thymidine
A
benzoic acid 5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester
B
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
at 20℃; for 1.5h; | A n/a B 93% |
4,4'-dimethoxytrityl chloride
A
5'-O-(4-4'-dimethoxytrityl)thymidine
B
3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine
Conditions | Yield |
---|---|
With pyridine at 20℃; for 0.5h; | A 93% B n/a |
With pyridine at 20℃; for 1.5h; | A 93% B n/a |
1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
A
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
In methanol for 0.75h; Irradiation; | A n/a B 92% |
In methanol for 0.75h; Irradiation; | A 92% B 91% |
triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
With pivaloyl chloride; ethylene glycol at 0℃; for 0.333333h; Hydrolysis; | 91% |
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
With tri-n-butyl-tin hydride In toluene at 115℃; for 0.0833333h; | 82% |
5'-O-(4-4'-dimethoxytrityl)thymidine
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran; water for 3h; Ambient temperature; | 73% |
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Molecular Structure of 5'-O-dimethoxytrityl-deoxythymidine (CAS NO.40615-39-2):
IUPAC Name: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
Cas register number: 40615-39-2
Molecular formula: C31H32N2O6
Molecular Weight: 528.6
Density: 1.272 g/cm3
Index of Refraction: 1.602
Molar Refractivity: 146.9 cm3
Molar Volume: 427.8 cm3
Polarizability: 58.23×10-24cm3
Surface Tension: 51.6 dyne/cm
Appearance: White Powder
Product Categories: Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides.
Safety Statements about 5'-O-dimethoxytrityl-deoxythymidine (CAS NO.40615-39-2):
Hazard Codes:
Xi:
R36/37/38: Irritating to eyes, respiratory system and skin.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
F1: Sensitive to air and humidity.
F3: Hygroscopic.
F10: Keep under argon.
WGK Germany: 3
Hazard Note: Irritant
5'-O-dimethoxytrityl-deoxythymidine , its cas register number is 40615-39-2. It also can be called 5’-O-[bis(4-methoxyphenyl)phenylmethyl]-thymidin ; 5'-Dimethoxytrityl thymidine ; 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine ; 5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxythymidine ; 5'-O-(4,4'-dimethoxytrityl)thymidine ; 5-O-(4,4-dimethoxytrityl)thymidine ; 5'-O-dimethoxytrityl-deoxythymidine ; 5'-O-(dimethoxytrityl)-thymidine . Some useful informationabout Handling and Storage: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse.Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.Keep refrigerated. (Store below 4°C/39°F.) Keep container closed when not in use. Store in a dry area.