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CAS No.: | 516-38-1 |
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Name: | ALPHA-CORTOL |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C21H36 O5 |
Molecular Weight: | 368.514 |
Synonyms: | 5b-Pregnane-3a,11b,17,20a,21-pentol (7CI,8CI); 20a-Cortol; 3a,11b,17,20a,21-Pentahydroxypregnane; Cortol; NSC 60459; a-Cortol |
Density: | 1.252g/cm3 |
Melting Point: | 250.5-254oC |
Boiling Point: | 564.5°Cat760mmHg |
Flash Point: | 255°C |
PSA: | 101.15000 |
LogP: | 1.44510 |
3α,20αF,21-triacetoxy-17-hydroxy-5β-pregnan-11-one
5β-pregnane-3α,11β,17α,20β,21-pentaol
Conditions | Yield |
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With lithium aluminium tetrahydride |
20α-cortol 20,21-diacetate
5β-pregnane-3α,11β,17α,20β,21-pentaol
Conditions | Yield |
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saponification; |
methyl 20β-acetoxy-3α-tert-butyldimethylsilyloxy-17α-hydroxy-11-oxo-5β-pregnan-21-oate
5β-pregnane-3α,11β,17α,20β,21-pentaol
Conditions | Yield |
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Multi-step reaction with 4 steps 1: 410 mg / LiAlH4 / diethyl ether / 1 h / Ambient temperature 2: 250 mg / pyridine / Ambient temperature 3: 100 mg / 50percent H2SO4 / acetone / 0.17 h / Ambient temperature 4: saponification View Scheme |
20α-cortol 3-tert-butyldimethylsilyl ether
5β-pregnane-3α,11β,17α,20β,21-pentaol
Conditions | Yield |
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Multi-step reaction with 3 steps 1: 250 mg / pyridine / Ambient temperature 2: 100 mg / 50percent H2SO4 / acetone / 0.17 h / Ambient temperature 3: saponification View Scheme |
20α-cortol 3-tert-butyldimethylsilyl ether 20,21-diacetate
5β-pregnane-3α,11β,17α,20β,21-pentaol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 100 mg / 50percent H2SO4 / acetone / 0.17 h / Ambient temperature 2: saponification View Scheme |
5β-pregnane-3α,11β,17α,20β,21-pentaol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium acetate; acetic acid 2: LiAlH4 View Scheme |
5β-pregnane-3α,11β,17α,20β,21-pentaol
5β-pregnane-3α,11β,17α,20β,21-pentaol 3,11,21-tris-DEHS-17,20-DES derivate
Conditions | Yield |
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In pyridine for 1h; Ambient temperature; |
Conditions | Yield |
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With pyridine; chloro-trimethyl-silane |