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CAS No.: | 53179-11-6 |
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Name: | Loperamide |
Article Data: | 8 |
Molecular Structure: | |
Formula: | C29H33 Cl N2 O2 |
Molecular Weight: | 477.046 |
Synonyms: | ADL2-1294; Loperamide |
EINECS: | 258-416-5 |
Density: | 1.187g/cm3 |
Boiling Point: | 647.2 °C at 760 mmHg |
Flash Point: | 345.2 °C |
Hazard Symbols: | C,Xi |
Risk Codes: | R34; R36/37/38; R41; R37/38; R20/21/22 |
PSA: | 43.78000 |
LogP: | 5.02590 |
loperamide
Conditions | Yield |
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With sodium tetrahydroborate In ethanol; water at 50 - 60℃; chemoselective reaction; | 95% |
4-(4-chlorophenyl)-4-hydroxypiperidine
N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide
loperamide
Conditions | Yield |
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With sodium carbonate In N,N-dimethyl-formamide at 80℃; | 80% |
With sodium carbonate; 4-methyl-2-pentanone at 80℃; Dean-Stark; Reflux; | 38% |
4-Bromo-2,2-diphenylbutyric acid
loperamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: thionyl chloride; dimethylformamide / CHCl3 / 4 h / Heating 2: Na2CO3 / tetrahydrofuran 3: 80 percent / Na2CO3 / dimethylformamide / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride / chloroform / 4 h / Reflux 2: sodium carbonate / water; toluene / 0 - 20 °C 3: 4-methyl-2-pentanone; sodium carbonate / 80 °C / Dean-Stark; Reflux View Scheme |
4-bromo-2,2-diphenylbutyric acid chloride
loperamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Na2CO3 / tetrahydrofuran 2: 80 percent / Na2CO3 / dimethylformamide / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate / water; toluene / 0 - 20 °C 2: 4-methyl-2-pentanone; sodium carbonate / 80 °C / Dean-Stark; Reflux View Scheme |
3,3-Diphenyl-dihydro-furan-2-one
loperamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogen bromide; acetic acid / 48 h / 20 °C 2: thionyl chloride / chloroform / 4 h / Reflux 3: sodium carbonate / water; toluene / 0 - 20 °C 4: 4-methyl-2-pentanone; sodium carbonate / 80 °C / Dean-Stark; Reflux View Scheme |
loperamide
Conditions | Yield |
---|---|
With dihydrogen peroxide In methanol for 168h; |