CAS No.56602-33-6,Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	56602-33-6
Name:	Benzotriazol-1-yloxytris(dimethylamino)-phosphonium hexafluorophosphate
Article Data:	2

Formula:	C₁₂H₂₂N₆OP^.PF₆
Molecular Weight:	442.284
Synonyms:	Btzo-tdmap;Phosphorus(1++), (1-hydroxy-1H-benzotriazolato-O)tris(N-methylmethanaminato)-, (beta-4)-, hexafluorophosphate(1-);Bop reagent;Tri(dimethylamino)benzotriazol-1-yloxyphosphonium hexafluorophosphate;Phosphorus(1+),(1-hydroxy-1Hbenzotriazolato- O)tris(N-methylmethanaminato)-,(T-4)-,hexafluorophosphate(1-);(1H-Benzotriazol-1-yloxy)-tris(dimethylamino)phosphonium hexafluorophosphate(1-);Phosphorus(1+), (1H-benzotriazol-1-olato-O)tris(N-methylmethanaminato)-, (T-4)-;BOP-Reagent;Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium;BOP hexafluorophosphate;Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate;
EINECS:	260-279-1
Melting Point:	>130 °C (dec.)(lit.)
Flash Point:	138 °C
Solubility:	methanol: 25 mg/mL, clear
Appearance:	white to off-white powder
Hazard Symbols:	Xi
Risk Codes:	37/38-44-36/37/38
Safety:	24/25-37/39-36-26
Transport Information:	UN 1325 4.1/PG 2
PSA:	76.84000
LogP:	4.60470

Synthetic route

: 2592-95-2
benzotriazol-1-ol

: chlorotris(dimethylamino)phosphonium hexafluorophosphate

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

Conditions

Conditions	Yield
With TEA In acetone for 1h;

: 680-31-9
N,N,N,N,N,N-hexamethylphosphoric triamide

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 72 percent / potassium hexafluorophosphate; oxalyl chloride; DMF / acetonitrile / 4 h / 0 - 20 °C 2: TEA / acetone / 1 h View Scheme

: 957187-25-6
5-amino-4-chloro-2-fluorobenzoic acid

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 1386981-39-0
1H-benzo[d][1,2,3]triazol-1-yl 5-amino-4-chloro-2-fluorobenzoate

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 0℃; for 3h;	98.8%

: 300354-95-4
3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid

: 32955-21-8
2-amino-thiazole-5-carboxylic acid ethyl ester

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 588940-26-5
2-[3-cyclopentyl-2-(4-methanesulfonyl-phenyl)-propionylamino]-thiazole-5-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane	98%

...Expand

: 1076-38-6
4-hydroxy[1]benzopyran-2-one

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-2H-chromen-2-one

Conditions

Conditions	Yield
Stage #1: 4-hydroxy[1]benzopyran-2-one With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20℃; for 0.166667h; Stage #2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In acetonitrile at 20℃; for 1h;	97%

: 96-50-4
2-thiazolylamine

: 300355-34-4
3-cyclopentyl-2-(3,4-dichlorophenyl)propionic acid

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 3-cyclopentyl-2-(3,4-dichlorophenyl)-N-thiazol-2-yl-propionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane	96%
With triethylamine In dichloromethane	96%

...Expand

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: 93778-57-5
9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-1H-purin-6(9H)-one

: (2R,3S,5R)-5-(6-(1H-benzo[d][1,2,3]triazol-1-yloxy)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-ol

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;	95%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 40h;	85%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 40h;	85%

: 96-50-4
2-thiazolylamine

: 2-(4-benzoylamino-phenyl)-3-cyclopentyl-propionic acid

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: N-{4-[2-cyclopentyl-1-(thiazol-2-ylcarbamoyl)-ethyl]-phenyl}-benzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane	95%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 300355-34-4
3-cyclopentyl-2-(3,4-dichlorophenyl)propionic acid

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: N-(1H-benzoimidazol-2-yl)-3-cyclopentyl-2-(3,4-dichloro-phenyl)-propionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane	95%

...Expand

: 934-32-7
1H-benzimidazol-2-amine

: 300355-72-0
2-(3-cyano-4-methanesulfonylphenyl)-3-cyclopentylpropionic acid

: 56602-33-6
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

: N-(1H-benzoimidazol-2-yl)-2-(3-cyano-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane	95%

...Expand

Raw Materials

680-31-9

Downstream Products

680-31-9

Total:146 Page 1 of 4 1 2 3 4 Next>>

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Standards and Recommendations

Purity: 99%min
Loss on dryging: 0.5%max
Heavy metals: 20 ppm max

Specification

BOP , with the CAS register number 56602-33-6 , is also known to us as (1-hydroxy-1h-benzotriazolato-o)tris(n-methylmethanaminato)-phosphorus(1++;benzotriazol-1-yl-oxytris(dimethylamino)phosphoniumhexa-fluorophosphate(bop) , BENZOTRIAZOLYL-N-OXYTRIS-(DIMETHYLAMINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE) , BENZOTRIAZOLE-1-YL-OXY-TRIS-DIMETHYLAMINOPHOPHONIUM ,etc.

Some characteristics of this chemical are as below: (1)Melting point 136-140°C ; (2)Decomposition 138°C. It is a kind of white to off-white powder and it is soluble in the methanol 25 mg/mL. And it is sensitive to the moisture and light. As for its usage, it could be used as peptide coupling reagent and it is also applied in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis. While storing, it should be put in a 2-8 °C environment.

Being a kind of irritant chemical, it may cause inflammation to the skin or other mucous membranes. For one thing, it is irritant to eyes, respiratory system and skin, and for another, it has the risk of explosion if heated under confinement. So while using this chemical, you should wear suitable gloves and eye/face protection. And avoid contact with skin and eyes, but if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, if you need more safety information, you could refer to WGK Germany 3.

This kind of chemical belongs to the product categories which are as the following: Pharmaceutical Intermediates, Peptide Coupling Reagents & Miscellaneous Reagents, Biochemistry, Condensation & Active Esterification, Coupling Reactions (Peptide Synthesis), Phosphonium Compounds, Synthetic Organic Chemistry.

And you could also obtain the molecular structure by converting the following data information:
SMILES: F[P-](F)(F)(F)(F)F.n1nn(O[P+](N(C)C)(N(C)C)N(C)C)c2ccccc12
InChI: InChI=1/C12H22N6OP.F6P/c1-15(2)20(16(3)4,17(5)6)19-18-12-10-8-7-9-11(12)13-14-18;1-7(2,3,4,5)6/h7-10H,1-6H3;/q+1;-1
InChIKey: MGEVGECQZUIPSV-UHFFFAOYAP