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CAS No.: | 571-40-4 |
---|---|
Name: | 5-Androstenedione |
Article Data: | 27 |
Molecular Structure: | |
Formula: | C19H26O2 |
Molecular Weight: | 286.414 |
Synonyms: | 5a-Androst-1-ene-3,17-dione (8CI);1(5a)-Androstene-3,17-dione;1-Androstenedione;D1-5a-Androstene-3,17-dione; |
EINECS: | 571-400-4 |
Density: | 1.099 g/cm3 |
Melting Point: | 140-142 °C |
Boiling Point: | 418.8 °C at 760 mmHg |
Flash Point: | 156.6 °C |
PSA: | 34.14000 |
LogP: | 3.94330 |
Conditions | Yield |
---|---|
With palladium(II) trifluoroacetate; oxygen; acetic acid; dimethyl sulfoxide at 80℃; under 760.051 Torr; for 12h; | 93% |
With trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 60℃; for 40h; Temperature; regioselective reaction; | 63% |
With periodic acid; tert-butyl alcohol | |
With 3-ketosteroid Δ1-dehydrogenase Enzymatic reaction; |
Conditions | Yield |
---|---|
With chromium(VI) oxide In water; acetic acid at 25 - 30℃; for 1h; | 88.9% |
Conditions | Yield |
---|---|
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 70℃; for 24h; | A 4% B 84% |
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In fluorobenzene; dimethyl sulfoxide at 70℃; for 24h; Dehydrogenation; | A 4% B 84% |
Conditions | Yield |
---|---|
With 1-tosyloxy-1-oxo-1H-1λ5-benzo[d][1,2]iodoxol-3-one In dichloromethane at 20℃; for 10h; | A 45% B 17% |
Epiandrosterone
A
testosterone
B
3β,11α-dihydroxy-5α-androstan-17-one
C
3beta-7alpha-Dihydroxy-5alpha-androstane-17-one
D
3beta-7beta-Dihydroxy-5alpha-androstane-17-one
E
1α,3β-dihydroxy-5α-androstan-17-one
F
Androsta-1,4-diene-3,17-dione
G
1-dehydrotestosterone
H
6β-hydroxytestosterone
I
5α-androst-1-ene-3,17-dione
J
6β-hydroxy-4-androstene-3,17-dione
Conditions | Yield |
---|---|
With malt extract; disodium hydrogenphosphate; calcium(II) chloride dihydrate; magnesium(II) chloride hexahydrate; strontium (III) chloride hexahydrate; potassium chloride; boric acid; sodium hydrogencarbonate; sodium sulfate; sodium chloride; potassium bromide; potassium hydroxide In water; N,N-dimethyl-formamide at 32℃; for 168h; pH=8; Enzymatic reaction; | A 2% B 2% C 2% D 3% E 5% F 5% G 3% H 2% I 2% J 32% |
2,4,6-trimethyl-pyridine
2α-bromo-3,17-dioxo-5α-androstane
A
Androstenedione
B
5α-androst-1-ene-3,17-dione
(5S,8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
5α-androst-1-ene-3,17-dione
androstanedione
A
Androstenedione
B
Androsta-1,4-diene-3,17-dione
C
5α-androst-1-ene-3,17-dione
Conditions | Yield |
---|---|
With Phenylselenyl chloride; dihydrogen peroxide Yield given. Multistep reaction. Yields of byproduct given; |
2α-bromo-3,17-dioxo-5α-androstane
5α-androst-1-ene-3,17-dione
Conditions | Yield |
---|---|
With lithium carbonate; lithium bromide |
The CAS registry number of Androst-1-ene-3,17-dione,(5a)- is 571-40-4. It also can be called 1-Androstenedioneand. The IUPAC name is (5α)-androst-1-ene-3,17-dione. In addition, the molecular formula is C19H26O2 and the molecular weight is 286.41.
Physical properties about Androst-1-ene-3,17-dione,(5a)- are: (1)ACD/LogP: 2.86; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.86; (4)ACD/LogD (pH 7.4): 2.86; (5)ACD/BCF (pH 5.5): 87.87; (6)ACD/BCF (pH 7.4): 87.87; (7)ACD/KOC (pH 5.5): 857.04; (8)ACD/KOC (pH 7.4): 857.04; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 34.14 Å2; (13)Index of Refraction: 1.539; (14)Molar Refractivity: 81.63 cm3; (15)Molar Volume: 260.4 cm3; (16)Polarizability: 32.36 ×10-24cm3; (17)Surface Tension: 40.1 dyne/cm; (18)Density: 1.099 g/cm3; (19)Flash Point: 156.6 °C; (20)Enthalpy of Vaporization: 67.24 kJ/mol; (21)Boiling Point: 418.8 °C at 760 mmHg; (22)Vapour Pressure: 3.19E-07 mmHg at 25°C.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C4\C=C/[C@]2([C@@H](CC[C@H]3[C@@H]1CCC(=O)[C@@]1(C)CC[C@H]23)C4)C
(2)InChI: InChI=1/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h7,9,12,14-16H,3-6,8,10-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1
(3)InChIKey: WJIQCDPCDVWDDE-WZNAKSSCBX