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| CAS No.: | 60-41-3 |
|---|---|
| Name: | STRYCHNINE |
| Molecular Structure: | |
|
|
|
| Formula: | C21H22N2O2•1/2H2O4S |
| Molecular Weight: | 766.915 |
| Synonyms: | strychninesulphate;Strychninesulfate;97%;Strychninesulfate |
| Density: | 1.0926 (rough estimate) |
| Melting Point: |
284-286 °C(lit.) |
| Boiling Point: | 559.9oC at 760 mmHg |
| Flash Point: | 292.4oC |
| Hazard Symbols: | T+,N |
| Risk Codes: | 27/28-50/53-26/28 |
| Safety: | Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also STRYCHNINE and SULFATES. |
| PSA: | 148.54000 |
| LogP: | 4.61880 |
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- 60-41-3
(-)-strychninium sulfate
| Conditions | Yield |
|---|---|
| In not given react. of the rhombohedral crystallizing Ba{Co(NH3)2(C2O4)(NO2)2}2*H2O with the calculated amount of strychninesulfate;; fractionated crystallization;; | |
| In not given react. of the rhombohedral crystallizing Ba{Co(NH3)2(C2O4)(NO2)2}2*H2O with the calculated amount of strychninesulfate;; fractionated crystallization;; |
- 60-41-3
(-)-strychninium sulfate
| Conditions | Yield |
|---|---|
| In water equimolar amts. of Cr salt (cold H2O soln.) and strychninium sulfate (cold satd. soln.);; |
- 60-41-3
(-)-strychninium sulfate
| Conditions | Yield |
|---|---|
| In water addn. of a cold satd. soln. of the oxalate to a cold satd. soln. of the sulfate; crystn.;; | |
| In water addn. of a cold satd. soln. of the oxalate to a cold satd. soln. of the sulfate; crystn.;; |
| Conditions | Yield |
|---|---|
| In water addn. of a cold satd. soln. of the oxalate to a cold satd. soln. of the nitrate; crystn.;; | |
| In water addn. of a cold satd. soln. of the oxalate to a cold satd. soln. of the nitrate; crystn.;; |
- 60-41-3
(-)-strychninium sulfate
| Conditions | Yield |
|---|---|
| In water byproducts: BaSO4;; warming the Ba salt with the calcd. amt. of strychninium sulfate; extractn. of the ppt. with boiling H2O, crystn. from the filtrate:; | |
| In water byproducts: BaSO4;; warming the Ba salt with the calcd. amt. of strychninium sulfate; extractn. of the ppt. with boiling H2O, crystn. from the filtrate:; |
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Chemistry
Product Name: Strychnine (60-41-3)
Synonyms: (-)-Strychnine ; Strychnine ; Strychnine alkaloid ; Strychnine hemisulfate ; Strychnine hemisulfate salt ; Strychnine sulfate ; Strychnine sulphate ; Antivampire
CAS: 60-41-3
MF: C21H22N2O2
MW: 334.41
EINECS: 200-319-7
Product Categories: Alkaloids;Biochemistry;for Resolution of Acids;Indole Alkaloids;Optical Resolution;Synthetic Organic Chemistry;Amino Acids;I - Z;Modified Amino Acids
Mol File: 60-41-3.mol
Melting point: 284-286 °C(lit.)
Appearance: Strychnine sulfate (2:1) (60-41-3) is colorless, odorless, very bitter crystals or white crystalline powder.
Solubility : chloroform: clear to hazy
Merck : 8855
Uses
Strychnine sulfate (2:1) (60-41-3) has been used as a tonic and stimulant in veterinary medicine and registered as a rodenticide in the U.S.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| bird - wild | LD50 | oral | 5600ug/kg (5.6mg/kg) | | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. |
| cat | LD50 | intravenous | 2500ug/kg (2.5mg/kg) | | Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936. |
| child | LDLo | oral | 3367ug/kg (3.367mg/kg) | behavioral: general anesthetic | Journal of Forensic Sciences. Vol. 30, Pg. 1248, 1985. |
| guinea pig | LD50 | intraperitoneal | 10900ug/kg (10.9mg/kg) | behavioral: convulsions or effect on seizure threshold | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963. |
| guinea pig | LD50 | intravenous | 390ug/kg (0.39mg/kg) | behavioral: convulsions or effect on seizure threshold | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963. |
| guinea pig | LD50 | subcutaneous | 4800ug/kg (4.8mg/kg) | behavioral: convulsions or effect on seizure threshold | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963. |
| man | LDLo | oral | 37mg/kg (37mg/kg) | behavioral: convulsions or effect on seizure threshold | Journal of Analytical Toxicology. Vol. 10, Pg. 120, 1986. |
| mouse | LD50 | intraperitoneal | 900ug/kg (0.9mg/kg) | | International Journal for Vitamin and Nutrition Research, Supplement. Vol. 16, Pg. 31, 1977. |
| mouse | LD50 | intravenous | 475ug/kg (0.475mg/kg) | | Journal of Pharmacology and Experimental Therapeutics. Vol. 79, Pg. 127, 1943. |
| mouse | LD50 | subcutaneous | 1250ug/kg (1.25mg/kg) | | Journal of Pharmacology and Experimental Therapeutics. Vol. 67, Pg. 153, 1939. |
| mouse | LDLo | oral | 8mg/kg (8mg/kg) | | Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985. |
| rat | LD50 | intraperitoneal | 1mg/kg (1mg/kg) | behavioral: convulsions or effect on seizure threshold | Arzneimittel-Forschung. Drug Research. Vol. 23, Pg. 1125, 1973. |
| rat | LD50 | intravenous | 570ug/kg (0.57mg/kg) | behavioral: convulsions or effect on seizure threshold | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 144, Pg. 416, 1963. |
| rat | LD50 | oral | 2600ug/kg (2.6mg/kg) | | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 31, Pg. 113, 1942. |
| rat | LD50 | subcutaneous | 1700ug/kg (1.7mg/kg) | | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
| women | TDLo | oral | 6800ug/kg (6.8mg/kg) | behavioral: convulsions or effect on seizure threshold | Canadian Medical Association Journal. Vol. 124, Pg. 1268, 1981. |
Safety Profile
Hazard Codes: T+.gif){kind=small}
,N .gif){kind=small}
Risk Statements: 26/27/28-50/53
26/27/28: Very Toxic by inhalation, in contact with skin and if swallowed
50/53: Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements: 36/37-45-60-61-28-13
13: Keep away from food, drink and animal feeding stuffs
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
60: This material and/or its container must be disposed of as hazardous waste
61: Avoid release to the environment. Refer to special instructions safety data sheet
36/37: Wear suitable protective clothing and gloves
RIDADR: UN 1692 6.1/PG 1
WGK Germany: 3
RTECS : WL2550000
HazardClass: 6.1(a)
PackingGroup I
Specification
1.Reactivity Profile :Strychnine sulfate (2:1) (60-41-3) is an alkaloid derivative. Strychnine is a base and forms water soluble salts with acids. Avoid alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light. [EPA, 1998] Strychnine is incompatible with the following: Strong oxidizers .
2.Health Hazard: Violent poison!. Lowest published lethal dose orally in humans is 30 mg/kg.
3.Fire Hazard: When heated to decomposition, Strychnine emits very toxic fumes of sulfur oxides and nitrogen oxides. Avoid alkalies, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light.