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66069-34-9

Basic Information
CAS No.: 66069-34-9
Name: (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 2-methylpropan-2-amine
Article Data: 2
Molecular Structure:
Molecular Structure of 66069-34-9 ((2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 2-methylpropan-2-amine)
Formula: C12H20N2O5
Molecular Weight: 272.301
Synonyms: compound with tert-butylamine;[2R-(2alpha,3Z,5alpha)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, compound with tert-butylamine (1:1);t-butylammonium clavulanate;(2R-(2α,3Z,5α))-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, compound with tert-butylamine (1:1);(2R,5R)-3-[2-Hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid;[2R-(2α,3Z,5α)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, compound with tert-butylamine (1:1);
Density: g/cm3
Boiling Point: 545.8°Cat760mmHg
Flash Point: 283.9°C
PSA: 113.09000
LogP: 0.28620
Synthetic route
75-64-9

tert-butylamine

58001-44-8

clavulanic acid

66069-34-9

clavulanic acid tert-butylamine

Conditions
ConditionsYield
In ethyl acetate81%
In ethyl acetate; isopropyl alcohol for 1h;77%
In ethanol; ethyl acetate43%
Stage #1: clavulanic acid With ammonium sulfate In water; ethyl acetate at 5℃; pH=1.30;
Stage #2: tert-butylamine In methanol; ethyl acetate at 5℃; for 2h; pH-value; Concentration;
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