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CAS No.: | 66069-34-9 |
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Name: | (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 2-methylpropan-2-amine |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C12H20N2O5 |
Molecular Weight: | 272.301 |
Synonyms: | compound with tert-butylamine;[2R-(2alpha,3Z,5alpha)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, compound with tert-butylamine (1:1);t-butylammonium clavulanate;(2R-(2α,3Z,5α))-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, compound with tert-butylamine (1:1);(2R,5R)-3-[2-Hydroxy-eth-(Z)-ylidene]-7-oxo-4-oxa-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid;[2R-(2α,3Z,5α)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, compound with tert-butylamine (1:1); |
Density: | g/cm3 |
Boiling Point: | 545.8°Cat760mmHg |
Flash Point: | 283.9°C |
PSA: | 113.09000 |
LogP: | 0.28620 |
Conditions | Yield |
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In ethyl acetate | 81% |
In ethyl acetate; isopropyl alcohol for 1h; | 77% |
In ethanol; ethyl acetate | 43% |
Stage #1: clavulanic acid With ammonium sulfate In water; ethyl acetate at 5℃; pH=1.30; Stage #2: tert-butylamine In methanol; ethyl acetate at 5℃; for 2h; pH-value; Concentration; |