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6740-86-9

Basic Information
CAS No.: 6740-86-9
Name: 1-bromocyclopentyl-o-chlorophenyl ketone
Molecular Structure:
Molecular Structure of 6740-86-9 (1-bromocyclopentyl-o-chlorophenyl ketone)
Formula: C12H12 Br Cl O
Molecular Weight: 287.584
Synonyms: Ketone,1-bromocyclopentyl o-chlorophenyl (7CI,8CI); 1-Bromocyclopentyl 2-chlorophenylketone; 1-Bromocyclopentyl o-chlorophenyl ketone
Density: 1.509g/cm3
Boiling Point: 323.7°C at 760 mmHg
Flash Point: 149.6°C
PSA: 17.07000
LogP: 4.23040
Synthetic route
6740-85-8

(2-chlorophenyl)(cyclopentyl)methanone

6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
With copper(ll) bromide In ethyl acetate at 77℃;99%
With N-Bromosuccinimide; toluene-4-sulfonic acid In dichloromethane for 6h;98%
With hydrogen bromide; dihydrogen peroxide In water at 70 - 80℃; for 3h; Temperature;96.8%
873-32-5

2-Chlorobenzonitrile

6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium; iodine / diethyl ether / 1 h
1.2: 16 h
2.1: N-Bromosuccinimide; toluene-4-sulfonic acid / dichloromethane / 6 h
View Scheme
Multi-step reaction with 2 steps
1: copper(I) bromide / diethyl ether / 16 h / 50 °C / Cooling with ice
2: copper(ll) bromide / ethyl acetate / 3 h / 80 °C / Cooling with ice
View Scheme
609-65-4

o-chlorobenzoyl chloride

6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Cyclopentane; aluminum (III) chloride / dichloromethane / -10 °C / Inert atmosphere; Reflux
2: hydrogen bromide; dihydrogen peroxide / water / 3 h / 70 - 80 °C
View Scheme
Multi-step reaction with 2 steps
1: Cyclopentane; aluminum (III) chloride / dichloromethane / 3 h
2: hydrogen bromide; dihydrogen peroxide / water / 3 h / 70 - 80 °C
View Scheme
142-29-0

cyclopentene

6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Cyclopentane; aluminum (III) chloride / dichloromethane / -10 °C / Inert atmosphere; Reflux
2: hydrogen bromide; dihydrogen peroxide / water / 3 h / 70 - 80 °C
View Scheme
6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

79499-57-3

(±)-1-((2-chlorophenyl)(imino)methyl)cyclopentan-1-ol

Conditions
ConditionsYield
With ammonia for 4h;95%
With ammonium hydroxide; ammonia at 25℃; for 120h; Inert atmosphere;81%
With ammonium hydroxide In methanol; dichloromethane; water at -40 - -25℃; for 1.3h; Large scale;75.8%
6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

74-89-5

methylamine

6740-87-0

1-((2-chlorophenyl)(methylimino)methyl)cyclopentan-1-ol

Conditions
ConditionsYield
With water at 15 - 20℃; for 48h; Mechanism;90.8%
In water at 20℃; for 72h;22 g
6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

79499-58-4

1-<(2-Chlorophenyl)iminomethyl>cyclopentanol hydrochloride

Conditions
ConditionsYield
Stage #1: (1-Bromocyclopentyl)(2-chlorophenyl)methanone With ammonium hydroxide In water at 25℃; for 120h;
Stage #2: With hydrogenchloride In diethyl ether; isopropyl alcohol at 0℃; for 3h; Cooling with ice;
69%
With hydrogenchloride; ammonia 1) 4 h, 2) i-PrOH; Yield given. Multistep reaction;
Multi-step reaction with 2 steps
1: ammonia; ammonium hydroxide / 120 h / 25 °C / Inert atmosphere
2: hydrogenchloride / diethyl ether; isopropyl alcohol / 0.03 h / 0 °C / Inert atmosphere
View Scheme
6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

35211-10-0

norketamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / 28percent ammonium hydroxide saturated with anhydrous ammonia / 168 h / Ambient temperature
2: 16 g / propan-2-ol / 120 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 1) liq. NH3, 2) HCl / 1) 4 h, 2) i-PrOH
2: 88 percent / various solvent(s) / 0.12 h / 180 °C
View Scheme
Multi-step reaction with 2 steps
1: ammonium hydroxide
2: isopropyl alcohol / 1 h / 170 °C / Sealed tube; Microwave irradiation
View Scheme
6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

(+)-ketamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / 28percent ammonium hydroxide saturated with anhydrous ammonia / 168 h / Ambient temperature
2: propan-2-ol / 120 h / Heating
View Scheme
6740-86-9

(1-Bromocyclopentyl)(2-chlorophenyl)methanone

(-)-ketamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / 28percent ammonium hydroxide saturated with anhydrous ammonia / 168 h / Ambient temperature
2: 16 g / propan-2-ol / 120 h / Heating
View Scheme
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