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CAS No.: | 73684-69-2 |
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Name: | miporamicin |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C37H61 N O13 |
Molecular Weight: | 727.89 |
Synonyms: | MycinamicinI, 14-hydroxy-; 4,17-Dioxabicyclo[14.1.0]heptadecane, mycinamicin I deriv.;Antibiotic A 11725II; Antibiotic AR 5-2; Miporamicin; Mirosamicin; Mirosamycin;Mycinamicin II; Mycinomycin II |
Density: | 1.22g/cm3 |
Melting Point: | 104°C |
Boiling Point: | 843.2°C at 760 mmHg |
Flash Point: | 463.7°C |
Safety: | Poison by intraperitoneal route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx. |
PSA: | 175.21000 |
LogP: | 1.76370 |
mycinamicin II 3'-N-oxide
mycinamicin II
Conditions | Yield |
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With triphenylphosphine In dichloromethane at 55℃; for 67h; | 56% |
Conditions | Yield |
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With multifunctional biosynthetic P450 monooxygenase; rhodococcus reductase domain; NADPH In aq. buffer at 28℃; for 2h; pH=7.3; Kinetics; Reagent/catalyst; Enzymatic reaction; | A 18.5% B n/a C n/a D n/a E n/a |
mycinamicin V
mycinamicin II
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 39 percent / MCPBA, disodium hydrogen phosphate / CH2Cl2 / 23 h / 60 °C 2: 56 percent / triphenylphosphine / CH2Cl2 / 67 h / 55 °C View Scheme |
The IUPAC name of Mirosamicin (CAS NO.73684-69-2):
(1R,2S,3R,6E,8S,9S,10S,12R,14E,16R)-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-2-hydroxy-2-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-8,10,12-trimethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione
Synonyms: Miporamicin;A-11725II ; Antibiotic A-11725II ; Antibiotic AR-5-2 ; AR-5-2 ; Mycinamicin II
CAS: 73684-69-2
Molecular formula:C37H61NO13
Molecular Structure:
Molecular Weight 727.87914 g/mol
Index of Refraction: 1.545
Density: 1.22 g/cm3
Flash Point: 463.7 °C
Boiling Point: 843.2 °C at 760 mmHg
The toxicity of Mirosamicin (CAS NO.73684-69-2):
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 363mg/kg (363mg/kg) | Journal of Antibiotics. Vol. 33, Pg. 364, 1980. | |
mouse | LD50 | oral | 2gm/kg (2000mg/kg) | British UK Patent Application. Vol. #2020647A, | |
mouse | LD50 | subcutaneous | 465mg/kg (465mg/kg) | Journal of Antibiotics. Vol. 33, Pg. 364, 1980. |
The safety information of Mirosamicin (CAS NO.73684-69-2):
Poison by intraperitoneal route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.