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CAS No.: | 74457-86-6 |
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Name: | 2-Fluoro-4-methoxyacetophenone |
Article Data: | 7 |
Molecular Structure: | |
Formula: | C9H9FO2 |
Molecular Weight: | 168.168 |
Synonyms: | 1-(2-Fluoro-4-methoxyphenyl)ethanone;1-Acetyl-2-fluoro-4-methoxybenzene;2'-Fluoro-4'-methoxyacetophenone; |
Density: | 1.127 g/cm3 |
Melting Point: | 52-54 °C(lit.) |
Boiling Point: | 243 °C at 760 mmHg |
Flash Point: | 97.9 °C |
Solubility: | Insoluble in water |
Appearance: | white to light yellow crystal powder |
Hazard Symbols: | Xi |
Risk Codes: | 36/37/38 |
Safety: | 26-36-37/39 |
PSA: | 26.30000 |
LogP: | 2.03690 |
1-(4-methoxyphenyl)ethanone
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
Conditions | Yield |
---|---|
With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate In dichloromethane at 95℃; for 24h; Sealed tube; | 78% |
Multi-step reaction with 3 steps 1: sodium acetate / ethanol; water / 2 h / Reflux 2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N-fluorobis(benzenesulfon)imide; potassium nitrate / nitromethane / 24 h / 25 °C 3: hydrogenchloride; water / diethyl ether / 30 h / 20 °C View Scheme |
1-fluoro-3-methoxybenzene
acetic anhydride
A
1-(4-fluoro-2-methoxy-phenyl)-ethanone
B
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
Conditions | Yield |
---|---|
With lithium perchlorate at 100℃; for 1h; | A 30% B 70% |
1-fluoro-3-methoxybenzene
acetic anhydride
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
Conditions | Yield |
---|---|
With aluminium trichloride In carbon disulfide at 20 - 35℃; | 60.7% |
With aluminium trichloride In 1,2-dichloro-ethane for 2h; Ambient temperature; |
1-fluoro-3-methoxybenzene
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
C10H12FNO2
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
Conditions | Yield |
---|---|
With hydrogenchloride; water In diethyl ether at 20℃; for 30h; | 26.5 mg |
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
methylmagnesium chloride
2-(2-fluoro-4-methoxyphenyl)-2-isopropanol
Conditions | Yield |
---|---|
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone; methylmagnesium chloride In tetrahydrofuran; dichloromethane at 0℃; Inert atmosphere; Stage #2: With hydrogenchloride; methanol; water In tetrahydrofuran; dichloromethane at 20℃; Product distribution / selectivity; | 99% |
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone; methylmagnesium chloride In tetrahydrofuran at 20 - 35℃; for 0.666667h; Inert atmosphere; Stage #2: With water; acetic acid In tetrahydrofuran at 5 - 25℃; | 98% |
In tetrahydrofuran at -15 - 0℃; for 1h; | 95% |
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
2-fluoro-4-methoxy-phenol
Conditions | Yield |
---|---|
Stage #1: 1-(2-fluoro-4-methoxyphenyl)-1-ethanone With magnesium sulfate; 3-chloro-benzenecarboperoxoic acid In chloroform at 20℃; for 120h; Stage #2: With ammonium hydroxide In methanol; acetonitrile at 20℃; for 3h; Further stages.; | 98% |
Multi-step reaction with 2 steps 1: mCPBA, MgSO4 / CHCl3 / 12 h / Ambient temperature 2: 94 percent / aq. NH3 / methanol / 1 h / Ambient temperature View Scheme |
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
2-fluoro-4-methoxy-phenol
Conditions | Yield |
---|---|
In methanol | 94% |
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
(E)-1-(2-fluoro-4-methoxyphenyl)ethanone oxime
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water pH=5; Reflux; | 93% |
1-(2-fluoro-4-methoxyphenyl)-1-ethanone
Conditions | Yield |
---|---|
With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate In dichloromethane at 95℃; for 24h; Sealed tube; | 93% |
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