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CAS No.: | 756525-91-4 |
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Name: | BOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C16H31 N O8 |
Molecular Weight: | 365.424 |
Synonyms: | BOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID |
Density: | 1.124±0.06 g/cm3 (20 ºC 760 Torr) |
Boiling Point: | 504.5±50.0 °C(Predicted) |
Safety: | 24/25 |
PSA: | 112.55000 |
LogP: | 1.44310 |
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
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With palladium 10% on activated carbon; hydrogen In tetrahydrofuran under 760.051 Torr; for 24h; | 100% |
3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid
di-tert-butyl dicarbonate
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran; water at 20℃; Cooling with ice; | 93% |
2-<2-<2-<2-<(tert-Butoxycarbonyl)amino>ethoxy>ethoxy>ethoxy>ethanol
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4-methyl-morpholine / dichloromethane / 18 h / 20 °C 2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 24 h / 760.05 Torr View Scheme |
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
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With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 22℃; for 1.5h; | 100% |
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
---|---|
With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 22℃; for 3h; | 100% |
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
---|---|
With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 22℃; for 1h; | 100% |
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
(S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl piperazine-1-carboxylate
Conditions | Yield |
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With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 24h; | 99% |
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 5 - 20℃; | 98% |
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
---|---|
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 20℃; for 24h; | 96% |
1-hydroxy-pyrrolidine-2,5-dione
3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h; | 94% |
With dicyclohexyl-carbodiimide In dichloromethane | |
With dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 2h; | |
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; | |
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; |