Products Categories
CAS No.: | 763114-26-7 |
---|---|
Name: | 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid |
Article Data: | 33 |
Molecular Structure: | |
Formula: | C16H11FN2O3 |
Molecular Weight: | 298.273 |
Synonyms: | 2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoic acid |
EINECS: | 800-110-6 |
Density: | 1.42 |
PSA: | 83.31000 |
LogP: | 2.76350 |
4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one
carbon dioxide
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
Stage #1: 4-(3-bromo-4-fluorobenzyl)phthalazin-1(2H)-one With n-butyllithium In diethyl ether; hexane at -40 - -30℃; for 0.5h; Stage #2: carbon dioxide In diethyl ether; hexane for 0.333333h; Stage #3: With hydrogenchloride In water at 20℃; for 0.5h; Temperature; | 95.1% |
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
Stage #1: methyl 2-fluoro-5-(3-oxo-3H-isobenzofuran-1-ylmethylene)benzoate With hydrazine hydrate In tetrahydrofuran; water at 8 - 25℃; for 4h; Stage #2: With sodium hydroxide In tetrahydrofuran; water; acetone at 40℃; for 3.3h; | 95% |
2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With water; sodium hydroxide at 90℃; for 1h; Stage #2: With hydrazine hydrate at 70℃; for 18h; | 93.7% |
Stage #1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With sodium hydroxide In water at 90℃; for 1h; Stage #2: With hydrazine hydrate In water at 70℃; for 18h; | 93.69% |
Stage #1: 2-fluoro-5-(3-oxo-1,3-dihydroisobenzofuranylidene methyl)benzonitrile With hydrazine hydrate at 8 - 25℃; for 4h; Stage #2: With water; sodium hydroxide In acetone at 20 - 90℃; for 1h; | 91% |
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water at 20℃; | 93% |
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
With potassium hydroxide In methanol for 6h; Reflux; | 90.5% |
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; hydrazinium sulfate In water; isopropyl alcohol Reflux; | 85.1% |
dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate
2-fluoro-5-formyl-benzoic acid
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
Stage #1: dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate; 2-fluoro-5-formyl-benzoic acid With triethylamine In tetrahydrofuran at 0 - 20℃; for 5h; Stage #2: With hydrazine hydrate In tetrahydrofuran at 70℃; for 3h; | 83% |
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
Stage #1: (Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle; 2-fluoro-5-[(E)-(3-oxo-2-benzofuran-1-ylidene)methyl]benzonitrile With sodium hydroxide In water at 90℃; for 0.5h; Stage #2: With hydrazine In water at 70℃; for 18h; Stage #3: With hydrogenchloride at 20℃; for 0.166667h; pH=4; | 77% |
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
With sodium hydroxide; hydrazine hydrate In water | 77% |
Stage #1: (Z)-2-fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrle With water; sodium hydroxide at 90℃; for 16h; Inert atmosphere; Stage #2: With hydrazine hydrate at 70℃; for 16h; Inert atmosphere; |
2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
Conditions | Yield |
---|---|
Stage #1: 2-fluoro-4-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile With water; sodium hydroxide at 90℃; for 1h; Stage #2: With hydrazine hydrate at 70℃; for 18h; | 77% |