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CAS No.: | 77614-16-5 |
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Name: | DERMORPHIN ACETATE |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C40H50N8O10 |
Molecular Weight: | 802.885 |
Synonyms: | H-Tyr-D-ala-phe-gly-tyr-pro-ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;Dermorphin; |
Density: | 1.363g/cm3 |
Melting Point: | 157-159 °C |
Boiling Point: | 1323.8°C at 760 mmHg |
Flash Point: | 754.4°C |
PSA: | 314.05000 |
LogP: | 3.98630 |
dermorphin
Conditions | Yield |
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With formic acid; palladium | 80% |
BOC-glycine
1-(tert-butoxycarbonyl)-L-proline
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine
BOC-O-benzyl-L-serine
dermorphin
Conditions | Yield |
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Yield given. Multistep reaction; |
N-(fluoren-9-ylmethoxycarbonyl)glycine
Fmoc-Pro-OH
N-Fmoc L-Phe
Fmoc-Ser(tBu)-OH
Fmoc-Tyr(tBu)-OH
N-(9-fluorenylmethoxycarbonyl)-D-alanine
dermorphin
Conditions | Yield |
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Stage #1: Fmoc-Ser(tBu)-OH With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: With piperidine In 1-methyl-pyrrolidin-2-one for 0.333333h; Stage #3: N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Pro-OH; N-Fmoc L-Phe; Fmoc-Tyr(tBu)-OH; N-(9-fluorenylmethoxycarbonyl)-D-alanine Further stages; |
dermorphin
4-nitrophenol acetate
N-Acetyl-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
Conditions | Yield |
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In N,N-dimethyl-formamide at 0℃; for 12h; | 76% |
dermorphin
Conditions | Yield |
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With [bis(pyridine)iodine]+ tetrafluoroborate In dichloromethane at 20℃; for 0.166667h; Iodination; |