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CAS No.: | 80715-22-6 |
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Name: | 4-Bromomethyl-5-methyl-1,3-dioxol-2-one |
Article Data: | 31 |
Molecular Structure: | |
Formula: | C5H5BrO3 |
Molecular Weight: | 192.997 |
Synonyms: | (5-Methyl-2-oxo-1,3-dioxol-4-yl)methylbromide;5-(Bromomethyl)-4-methyl-2-oxo-1,3-dioxole; |
EINECS: | 807-002-8 |
Density: | 1.742 g/cm3 |
Melting Point: | 188-190°C(lit.) |
Boiling Point: | 180.518 °C at 760 mmHg |
Flash Point: | 62.976 °C |
Hazard Symbols: | Xi |
Risk Codes: | R36/37/38 |
PSA: | 43.35000 |
LogP: | 1.43610 |
4,5-Dimethyl-1,3-dioxole-2-one
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
Conditions | Yield |
---|---|
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane at 85℃; for 16h; Inert atmosphere; | 95% |
With N-Bromosuccinimide In chloroform Reflux; Large scale; | 93.8% |
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 77℃; for 6h; | 92% |
4,5-Dimethyl-1,3-dioxole-2-one
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
Conditions | Yield |
---|---|
With N-Bromosuccinimide In tetrachloromethane | 90% |
4-chloromethyl-5-methyl-1,3-dioxol-2-one
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
Conditions | Yield |
---|---|
With sodium bromide In N,N-dimethyl-formamide at 20℃; for 1h; | 75% |
With sodium bromide In N,N-dimethyl-formamide at 20℃; for 1h; | |
With sodium bromide In N,N-dimethyl-formamide at 20℃; for 1.5h; | |
With sodium bromide In N,N-dimethyl-formamide; acetone at 40 - 45℃; for 5h; Product distribution / selectivity; |
4,5-Dimethyl-1,3-dioxole-2-one
azobisisobutyronitrile
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
Conditions | Yield |
---|---|
With N-Bromosuccinimide In tetrachloromethane | 48% |
With N-Bromosuccinimide In tetrachloromethane |
N-Bromosuccinimide
4,5-Dimethyl-1,3-dioxole-2-one
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
Conditions | Yield |
---|---|
2,2'-azobis(isobutyronitrile) In benzene at 20℃; for 0.5h; Heating / reflux; |
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
trityl olmesartan medoxomil
Conditions | Yield |
---|---|
Stage #1: 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-1H-tetrazole; ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate With tert-butylamine hydrobromide; potassium carbonate In acetone at 0 - 55℃; for 32h; Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one With potassium carbonate; potassium iodide In acetone at 20 - 55℃; for 3h; | 98.5% |
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
ulifloxacin
prulifloxacin
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In N,N-dimethyl-formamide at 0℃; for 5h; Large scale; | 95.4% |
With potassium hydrogencarbonate In N,N-dimethyl-formamide for 5h; Ambient temperature; | 62% |
Stage #1: ulifloxacin With potassium hydrogencarbonate In acetonitrile at 25 - 30℃; Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one at 15 - 30℃; for 27 - 28.25h; | |
Stage #1: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one; ulifloxacin With potassium hydrogencarbonate In N,N-dimethyl-formamide at 0 - 28℃; for 3 - 4h; Stage #2: With hydrogenchloride In chloroform; water for 0.25h; pH=0.8 - 1.0; | |
Stage #1: ulifloxacin With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 0.166667h; Stage #2: 4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one In acetonitrile at 10 - 30℃; for 21h; Product distribution / selectivity; |
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 20℃; | 95% |
carbon dioxide
L-phenylalanine
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide Ambient temperature; | 94% |
4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl iodide
Conditions | Yield |
---|---|
With potassium iodide In acetone Ambient temperature; | 92% |