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CAS No.: | 898562-94-2 |
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Name: | Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]- |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C25H20 N4 O |
Molecular Weight: | 392.46 |
Synonyms: | 2-[(4-(1-Methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl]quinoline;MP 10 |
Density: | 1.216g/cm3 |
Boiling Point: | 568.569ºC at 760 mmHg |
Flash Point: | 297.66ºC |
PSA: | 52.83000 |
LogP: | 5.27630 |
2-((4-(4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline
methylhydrazine
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
With sulfuric acid In ethanol at 20℃; for 1h; | 56% |
3-(dimethylamino)-2-(pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)prop-2-en-1-one
methylhydrazine
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
With sulfuric acid In ethanol at 20℃; for 1h; Inert atmosphere; | A 56% B 17% |
2-((4-(4-(pyridin-4-yl)-1H-pyrazol-5-yl)phenoxy)methyl)quinoline
methylhydrazine
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
With sulfuric acid In ethanol for 1h; Reflux; | A 51% B 23% |
2-Chloromethylquinoline
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: potassium carbonate / acetone / 22 h / 60 °C / Inert atmosphere 2.1: water; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane / 20 °C 3.1: thionyl chloride / chloroform / Inert atmosphere 4.1: triethylamine / dichloromethane 5.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice 5.2: -78 °C 6.1: 1 h / Reflux 7.1: hydrazine hydrate / methanol / 1 h / Reflux 8.1: sulfuric acid / ethanol / 1 h / Reflux View Scheme |
N-methoxy-N-methyl-4-(quinolin-2-ylmethoxy)-benzamide
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice 1.2: -78 °C 2.1: 1 h / Reflux 3.1: hydrazine hydrate / methanol / 1 h / Reflux 4.1: sulfuric acid / ethanol / 1 h / Reflux View Scheme |
2-(pyridin-4-yl)-1-(4-(quinolin-2-ylmethoxy)phenyl)ethanone
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1 h / Reflux 2: hydrazine hydrate / methanol / 1 h / Reflux 3: sulfuric acid / ethanol / 1 h / Reflux View Scheme |
4-(quinolin-2-ylmethyloxy)benzoic acid
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: thionyl chloride / chloroform / Inert atmosphere 2.1: triethylamine / dichloromethane 3.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice 3.2: -78 °C 4.1: 1 h / Reflux 5.1: hydrazine hydrate / methanol / 1 h / Reflux 6.1: sulfuric acid / ethanol / 1 h / Reflux View Scheme |
4-(2-Quinolinylmethoxy)benzoic acid methyl ester
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: water; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane / 20 °C 2.1: thionyl chloride / chloroform / Inert atmosphere 3.1: triethylamine / dichloromethane 4.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice 4.2: -78 °C 5.1: 1 h / Reflux 6.1: hydrazine hydrate / methanol / 1 h / Reflux 7.1: sulfuric acid / ethanol / 1 h / Reflux View Scheme |
4-(quinolin-2-ylmethyloxy)benzoyl chloride
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: triethylamine / dichloromethane 2.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice 2.2: -78 °C 3.1: 1 h / Reflux 4.1: hydrazine hydrate / methanol / 1 h / Reflux 5.1: sulfuric acid / ethanol / 1 h / Reflux View Scheme |
methyl 4-hydroxylbenzoate
A
2-({4-[1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: potassium carbonate / acetone / 22 h / 60 °C / Inert atmosphere 2.1: water; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane / 20 °C 3.1: thionyl chloride / chloroform / Inert atmosphere 4.1: triethylamine / dichloromethane 5.1: lithium diisopropyl amide / tetrahydrofuran / Cooling with ice 5.2: -78 °C 6.1: 1 h / Reflux 7.1: hydrazine hydrate / methanol / 1 h / Reflux 8.1: sulfuric acid / ethanol / 1 h / Reflux View Scheme |