CAS No.924-42-5,N-Methylolacrylamide Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	924-42-5
Name:	N-Methylolacrylamide
Article Data:	17

Formula:	C₄H₇NO₂
Molecular Weight:	101.105
Synonyms:	Acrylamide,N-(hydroxymethyl)- (6CI,8CI);MH 100;MH 100 (amide);Monomethylolacrylamide;N-(Hydroxymethyl)acrylamide;N-MAM;N-MAM P;NMA 60;NSC 553;Rocagil BT;U-Ramin T 80;
EINECS:	213-103-2
Density:	1.074 g/cm³
Melting Point:	74-75 °C
Boiling Point:	318.1 °C at 760 mmHg
Flash Point:	146.2 °C
Solubility:	<0.1 g/100 mL at 20.5 °C
Appearance:	white crystal powder
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	26
PSA:	49.33000
LogP:	-0.37070

Synthetic route

: 50-00-0
formaldehyd

: 79-06-1
2-propenamide

: 924-42-5
N-Methylolacrylamid

Conditions

Conditions	Yield
In water at 35 - 40℃; pH=7 - 9;	72%
Stage #1: formaldehyd; 2-propenamide With tetramethyl ammoniumhydroxide; 4-methoxy-phenol In water at 60℃; for 3h; Stage #2: With sulfuric acid In water for 24h; pH=7.5 - 8; Catalytic behavior; Reagent/catalyst; Temperature;	66.72%
With copper; potassium carbonate

: 50-00-0
formaldehyd

: 107-06-2
1,2-dichloro-ethane

: 79-06-1
2-propenamide

: 924-42-5
N-Methylolacrylamid

Conditions

Conditions	Yield
With sodium; xylene

...Expand

: 50-00-0
formaldehyd

: 121-44-8
triethylamine

: 79-06-1
2-propenamide

: 924-42-5
N-Methylolacrylamid

...Expand

: 50-00-0
formaldehyd

: 79-06-1
2-propenamide

A: N,N-dimethylolacrylamide

B: 924-42-5
N-Methylolacrylamid

Conditions

Conditions	Yield
With 4-methoxy-phenol; sodium hydroxide In water at 20 - 60℃; for 1h; pH=10.5;

...Expand

: 5308-25-8
4-ethylpiperazine

: 924-42-5
N-Methylolacrylamid

: 1610610-01-9
3-(4-ethylpiperazin-1-yl)-N-(hydroxymethyl)propanamide

Conditions

Conditions	Yield
at 20℃; for 1h; Michael Addition; Ionic liquid;	94%
With triethylamine In water at 20℃; for 1h; Michael Addition; Green chemistry;	92%
With [ADPQ][CH3COO] at 20℃; for 1h; Michael Addition;	90%

: 99-24-1
methyl galloate

: 924-42-5
N-Methylolacrylamid

: C12H13NO6

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 35℃; for 96h; Friedel-Crafts Alkylation;	93.27%

: 626-58-4
4-methylpiperidin

: 924-42-5
N-Methylolacrylamid

: 1610610-02-0
N-(hydroxymethyl)-3-(4-methylpiperidin-1-yl)propanamide

Conditions

Conditions	Yield
With [DABCO-PDO][OAc] In neat (no solvent) at 20℃; for 1h; Michael Addition; Green chemistry;	93%
With triethylamine In water at 20℃; for 1h; Michael Addition; Green chemistry;	91%

: 831-61-8
Ethyl gallate

: 924-42-5
N-Methylolacrylamid

: C13H15NO6

Conditions

Conditions	Yield
With sulfuric acid In ethanol at 35℃; for 96h; Friedel-Crafts Alkylation;	92.38%

: 110-91-8
morpholine

: 924-42-5
N-Methylolacrylamid

: 63737-25-7
N-(hydroxymethyl)-3-morpholinopropanamide

Conditions

Conditions	Yield
With [DABCO-PDO][OAc] In neat (no solvent) at 20℃; for 2h; Michael Addition; Green chemistry;	90%
at 20℃; for 2h; Michael Addition; Ionic liquid;	90%
With [ADPQ][CH3COO] at 20℃; for 2h; Michael Addition;	87%

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 924-42-5
N-Methylolacrylamid

: 1616578-06-3
3-(4-(2-hydroxyethyl)piperazin-1-yl)-N-(hydroxymethyl)propanamide

Conditions

Conditions	Yield
With [DABCO-PDO][OAc] In neat (no solvent) at 20℃; for 2.5h; Michael Addition; Green chemistry;	88%

Total:137 Page 1 of 4 1 2 3 4 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The N-(Hydroxymethyl)prop-2-enamide with CAS registry number of 924-42-5 is also known as 2-Propenamide, N-(hydroxymethyl)-. The IUPAC name and product name are the same. It belongs to product categories of Acrylamide and Methacrylamide; Acrylic Monomers; Monomers. Its EINECS registry number is 213-103-2. In addition, the formula is C₄H₇NO₂ and the molecular weight is 101.10. This chemcal is a white crystal powder and should be stored in sealed containers in ventilated, dry place avoid light at -20 °C for 3 months.

Physical properties about N-(Hydroxymethyl)prop-2-enamide are: (1)ACD/LogP: -1.48; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.48; (4)ACD/LogD (pH 7.4): -1.48; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 3.74; (8)ACD/KOC (pH 7.4): 3.74; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 3; (12)Index of Refraction: 1.459; (13)Molar Refractivity: 25.46 cm³; (14)Molar Volume: 93 cm³; (15)Surface Tension: 37.2 dyne/cm; (16)Density: 1.085 g/cm³; (17)Flash Point: 146.2 °C; (18)Enthalpy of Vaporization: 64.87 kJ/mol; (19)Boiling Point: 318.1 °C at 760 mmHg; (20)Vapour Pressure: 3.06E-05 mmHg at 25 °C.

Preparation of N-(Hydroxymethyl)prop-2-enamide: it is prepared by reaction of acrylamide with 37% formaldehyde solution. The reaction occurs in alkaline conditions.

N-(hydroxymethyl)prop-2-enamide is prepared by reaction of acrylamide with 37% formaldehyde solution.

Uses of N-(Hydroxymethyl)prop-2-enamide: it is a versatile cross-linking monomer. What's more, it can be used for fiber modification, resin processing, adhesives, treatment agent of paper, leather, metal surface, and also used as soil conditioner.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. Besides, it is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C=CC(=O)NCO
2. InChI: InChI=1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)
3. InChIKey: CNCOEDDPFOAUMB-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	420mg/kg (420mg/kg)		"Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds. New York, John Wiley & Sons, Inc., 1978Vol. 1, Pg. 306, 1978.
rabbit	LDLo	skin	16gm/kg (16000mg/kg)	BEHAVIORAL: TREMOR	Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 111, 1990.
rat	LD50	intraperitoneal	563mg/kg (563mg/kg)		Biochemical Pharmacology. Vol. 19, Pg. 2591, 1970.
rat	LD50	oral	474mg/kg (474mg/kg)		Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. Vol. 34, Pg. 183, 1979.