100360-44-9

Basic information

• Product Name: 4-N-benzoyl-5-bromo-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine
• Synonyms: 4-N-benzoyl-5-bromo-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine
• CAS NO: 100360-44-9
• Molecular Weight: 712.597
• Mol File: 100360-44-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-N-benzoyl-5-bromo-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-benzoyl-5-bromo-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine(100360-44-9)
• EPA Substance Registry System: 4-N-benzoyl-5-bromo-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine(100360-44-9)

Safety Data

• Hazardous Substances Data: 100360-44-9(Hazardous Substances Data)

Upstream product

• 951-77-9 2'-Deoxycytidine 
• 1022-79-3 5-bromo-2'-deoxycytidine 
• 148716-10-3 4-N-benzoyl-5-bromodeoxycytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 178925-43-4 4-N-benzoyl-5-bromo-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 

Relevant articles and documents

DNA duplexes and triplex-forming oligodeoxynucleotides incorporating modified nucleosides forming stable and selective triplexes

We have previously reported DNA triplexes containing the unnatural base triad G-PPI·C3, in which PPI is an indole-fused cytosine derivative incorporated into DNA duplexes and C3 is an abasic site in triplex-forming oligonucleotides (TFOs) introduced by a propylene linker. In this study, we developed a new unnatural base triad A-ψ·CR1 where ψ and CR1 are base moieties 2′-deoxypseudouridine and 5-substituted deoxycytidine, respectively. We examined several electron-withdrawing substituents for R1 and found that 5-bromocytosine (C Br) could selectively recognize ψ. In addition, we developed a new PPI derivative, PPIMe, having a methyl group on the indole ring in order to achieve selective triplex formation between DNA duplexes incorporating various Watson-Crick base pairs, such as T-A, C-G, A-ψ, and G-PPIMe, and TFOs containing T, C, CBr, and C3. We studied the selective triplex formation between these duplexes and TFOs using UV-melting and gel mobility shift assays.