100367-55-3

Basic information

• Product Name: 2-Cyano-5-nitropyridine
• Synonyms: 2-PYRIDINECARBONITRILE, 5-NITRO-;2-CYANO-5-NITROPYRIDINE;6-CYANO-3-NITROPYRIDINE;5-nitropyridine-2-carbonitrile;2-Pyridinecarbonitrile,5-nitro-(9CI);5-NITROPYRIDINE-2-CARBONITRILE,PURITY:95% MIN(HPLC);5-Nitropicolinonitrile;5-Nitro-2-pyridinecarbonitrile
• CAS NO: 100367-55-3
• Molecular Formula: C₆H₃N₃O₂
• Molecular Weight: 149.11
• EINECS: 1312995-182-4
• Product Categories: PYRIDINE;Aromatics Compounds;Aromatics;Bases & Related Reagents;Nucleotides;Pyridines
• Mol File: 100367-55-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 43 °C
• Boiling Point: 344.557 °C at 760 mmHg
• Flash Point: 162.183 °C
• Appearance: Green solid
• Density: 1.418 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Ethyl Acetate, Methanol
• PKA: -4.35±0.10(Predicted)
• CAS DataBase Reference: 2-Cyano-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-5-nitropyridine(100367-55-3)
• EPA Substance Registry System: 2-Cyano-5-nitropyridine(100367-55-3)

Safety Data

• Hazardous Substances Data: 100367-55-3(Hazardous Substances Data)

Usage

Description

2-Cyano-5-nitropyridine is an organic compound characterized by its green solid appearance. It is a derivative of pyridine, a heterocyclic compound, with a nitro group at the 5th position and a cyano group at the 2nd position. 2-Cyano-5-nitropyridine is known for its significant role as a synthetic intermediate in the chemical industry.

Uses

Used in Chemical Synthesis:
2-Cyano-5-nitropyridine is used as a synthetic intermediate for the production of various chemical compounds. Its unique structure allows it to be a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. The presence of both nitro and cyano functional groups makes it a versatile starting material for further chemical reactions and modifications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Cyano-5-nitropyridine is used as a key intermediate in the synthesis of various drug candidates. Its ability to be modified and functionalized makes it an essential component in the development of new medications with potential therapeutic applications.
Used in Agrochemical Industry:
2-Cyano-5-nitropyridine also finds application in the agrochemical industry, where it is used as a synthetic intermediate for the development of new pesticides and other crop protection agents. Its structural diversity and reactivity contribute to the creation of innovative and effective products for agricultural use.

InChI:InChI=1/C6H3N3O2/c7-3-5-1-2-6(4-8-5)9(10)11/h1-2,4H

Upstream product

• 59290-34-5 5-nitropyridine-2-carboxamide 
• 4487-59-6 2-bromo-5-nitropyridine 
• 544-92-3 copper(I) cyanide 
• 100-70-9 2-Cyanopyridine 
• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 143-33-9 sodium cyanide 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 773837-37-9 sodium cyanide 

Downstream Products

• 55338-73-3 5-amino-2-cyanopyridine 
• 15069-92-8 5-hydroxypicolinic acid 
• 24242-20-4 5-amino-pyridine-2-carboxylic acid 
• 30766-11-1 5-bromoisonicotinic acid 
• 32046-43-8 5-Iodpicolinsaeure 
• 29082-92-6 5-methoxypyridine-2-carboxylic acid 
• 86873-62-3 5-Acetylaminopyridin-2-carbonsaeure 
• 86873-61-2 5-Hydroxylaminopyridin-2-carbonsaeure 
• 1011244-92-0 5-nitro-N-(4-trifluoromethylphenyl)-2-pyridinecarboxamide 

Relevant articles and documents

The Synthesis of the High-Potency Sweetener, NC-00637. Part 2: Preparation of the Pyridine Moiety

The pyridine moiety within the high-potency sweetener, NC-00637 (1), 5-amino-2-cyanopyridine (4), was prepared from 2-hydroxy-5-nitropyridine (10). The sequence involved the conversion of the hydroxy group to bromide followed by substitution with cyanide to give 2-cyano-5-nitropyridine (8). Reduction of the nitro group proved to be troublesome when catalytic hydrogenation was used. Iron with an acid gave a reproducible reaction that could be used at scale.

QUINOLINE COMPOUNDS AS MODULATORS OF RAGE ACTIVITY AND USES THEREOF

Quinoline compounds are disclosed that have a formula represented by the following: and wherein Cy, R1, R4a, R4b, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diabetes complications, inflammation, and neurodegeneration, obesity, cancer, ischemia/reperfusion injury, cardiovascular disease and other diseases related to RAGE activity.

NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION

The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, W and X are as described herein, compositions including the compounds and methods of using the compounds.

COMPOUND HAVING BENZAMIDE SKELETON AND CYCLOOXYGENASE (COX-1)-SELECTIVE INHIBITORY ACTIVITY

This invention provides a novel COX-1-selective inhibitor. This invention relates to a novel compound represented by the formula below or a salt thereof. This invention also relates to an analgesic agent, an antiinflammatory agent, an antitumor agent, an antiplatelet aggregation agent, and a cyclooxygenase-1-selective inhibitor comprising, as an active ingredient, such compound or salt thereof.