100487-82-9Relevant articles and documents
AMINOMETHYL-BIARYL DERIVATIVES AS COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF
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Page/Page column 112, (2015/02/02)
The present invention provides a compound of formula (I), a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical com
8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS
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Page/Page column 124; 125, (2013/09/12)
Compounds of the formula I in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of Syk, and can be employed, inter alia, for the treatment of cancer, rheumatoid arthritis and / or systemic lupus
Indolin-2-one p38α inhibitors I: Design, profiling and crystallographic binding mode
Eastwood, Paul,González, Jacob,Gómez, Elena,Vidal, Bernat,Caturla, Francisco,Roca, Ramón,Balagué, Cristina,Orellana, Adelina,Domínguez, María
scheme or table, p. 4130 - 4133 (2011/08/10)
The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38α inhibitors. The predicted binding mode was confirmed by X-ray crystallography.