651780-27-7

Basic information

• Product Name: ethyl 6-bromobenzo[d]isoxazole-3-carboxylate
• Synonyms: ethyl 6-bromobenzo[d]isoxazole-3-carboxylate;6-Bromobenzo[d]isoxazole-3-carboxylic acid ethyl ester;Ethyl 6-bromobenzisoxazole-3-carboxylate;6-Bromobenzisoxazole-3-carboxylic acid ethyl ester
• CAS NO: 651780-27-7
• Molecular Formula: C₁₀H₈BrNO₃
• Molecular Weight: 270.08
• Mol File: 651780-27-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 361.3 °C at 760 mmHg
• Flash Point: 172.3 °C
• Appearance: /
• Density: 1.587
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -7.61±0.30(Predicted)
• CAS DataBase Reference: ethyl 6-bromobenzo[d]isoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-bromobenzo[d]isoxazole-3-carboxylate(651780-27-7)
• EPA Substance Registry System: ethyl 6-bromobenzo[d]isoxazole-3-carboxylate(651780-27-7)

Safety Data

• Hazardous Substances Data: 651780-27-7(Hazardous Substances Data)

Usage

General Description

Ethyl 6-bromobenzo[d]isoxazole-3-carboxylate is a chemical compound with a molecular formula C11H9BrN2O3. It belongs to the class of organic compounds known as benzoisoxazoles, which are heterocyclic aromatic compounds containing an isoxazole ring fused to a benzene ring. ethyl 6-bromobenzo[d]isoxazole-3-carboxylate is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has potential biological activity and is often employed as a building block in the production of various drugs and bioactive molecules. Ethyl 6-bromobenzo[d]isoxazole-3-carboxylate may have applications in the fields of medicine, agriculture, and chemical research.

Upstream product

• 141-52-6 sodium ethanolate 
• 100487-82-9 4-bromo-2-nitro-benzoic acid methyl ester 
• 875258-18-7 ethyl (4-bromo-3-nitrophenyl)acetate 
• 110-46-3 isopentyl nitrite 
• 64-17-5 ethanol 
• 199328-35-3 ethyl 2-(4-bromo-2-nitrophenyl)acetate 

Downstream Products

• 57764-49-5 ethyl 1,2-benzisoxazole-3-carboxylate 
• 1093631-61-8 ethyl 6-[4-({[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methyl}oxy)phenyl]-1,2-benzisoxazole-3-carboxylate 
• 1093632-05-3 ethyl 6-(4-hydroxyphenyl)-1,2-benzisoxazole-3-carboxylate 
• 668970-13-6 1,1-dimethylethyl 2-[(6-bromobenzoisoxazole-3-carbonyl)amino]-5-cyanobenzoate 
• 668970-09-0 ethyl 6-(2-methylphenyl)benzoisoxazole-3-carboxylate 
• 668970-58-9 6-(2-trifluoromethyl-phenyl)-benzo[d]isoxazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

BENZOISOXAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (e.g., indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.