57764-49-5

Basic information

• Product Name: 1,2-BENZISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 1,2-BENZISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;3-ethoxycarbonyl-1,2-benzisoxazole;ethyl 1,2-benzisoxazole-3-carboxylate;ethyl benzo[d]isoxazole-3-carboxylate;1,2-Benzisoxazole-3-carboxylic Acid Ethyl Ester 3-Ethoxycarbonyl-1,2-benzisoxazole;Benzisoxazole-3-carboxylic acid ethyl ester
• CAS NO: 57764-49-5
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18
• Mol File: 57764-49-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 59 °C
• Boiling Point: 307 °C at 760 mmHg
• Flash Point: 139.5 °C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 0.000745mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -6.30±0.30(Predicted)
• CAS DataBase Reference: 1,2-BENZISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BENZISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(57764-49-5)
• EPA Substance Registry System: 1,2-BENZISOXAZOLE-3-CARBOXYLIC ACID ETHYL ESTER(57764-49-5)

Safety Data

• Hazardous Substances Data: 57764-49-5(Hazardous Substances Data)

Usage

General Description

1,2-Benzisoxazole-3-carboxylic acid ethyl ester is a chemical compound often used in the synthesis of various pharmaceuticals and organic compounds. It is a carboxylic acid ester, which means it contains both an ester group and a carboxylic acid group. The compound possesses a benzene ring fused to an isoxazole ring, which gives it unique chemical and biological properties. It is commonly used as a building block in the synthesis of various drugs and organic compounds due to its reactivity and versatility in chemical reactions. Additionally, its structure and properties make it a valuable intermediate in the production of biologically active substances and pharmaceuticals.

InChI:InChI=1/C10H9NO3/c1-2-13-10(12)9-7-5-3-4-6-8(7)14-11-9/h3-6H,2H2,1H3

Upstream product

• 651780-27-7 ethyl 6-bromobenzo[d]isoxazole-3-carboxylate 
• 57764-48-4 hydroxyimino-(2-nitro-phenyl)-acetic acid ethyl ester 
• 31912-02-4 ethyl 2-nitrophenylacetate 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 

Downstream Products

• 668969-99-1 methyl 5-bromo-2-({[5-(chlorosulfonyl)-1,2-benzisoxazole-3-yl]carbonyl}amino)-5-cyanobenzoate 
• 75290-76-5 1-(benzo[d]isoxazol-3-yl)ethanone 
• 1082682-56-1 methyl benzo[d]isoxazole-3-carboxylate 
• 28691-51-2 3-carboxy-5-nitro-1,2-benzisoxazole 
• 28691-47-6 benzisoxazole-3-carboxylic acid 

Relevant articles and documents

CASPASE INHIBITOR AND PHARMACEUTICAL COMPOSITION, USE AND THERAPEUTIC METHOD THEREOF

Disclosed are a class of compounds as a caspase inhibitor, and in particular the compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the use of the compound in treating caspase-related diseases.

INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the α7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof

The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds (indazoles and benzothiazoles), which act as ligands for the α7 nACh receptor subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.