1007652-06-3

Basic information

• Product Name: N-[4-chloro-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide
• Synonyms: N-[4-chloro-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide
• CAS NO: 1007652-06-3
• Molecular Weight: 279.69
• Mol File: 1007652-06-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-[4-chloro-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-chloro-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide(1007652-06-3)
• EPA Substance Registry System: N-[4-chloro-2-(trifluoromethyl)phenyl]-2,2-dimethylpropanamide(1007652-06-3)

Safety Data

• Hazardous Substances Data: 1007652-06-3(Hazardous Substances Data)

Upstream product

• 125686-52-4 N-<2-(trifluromethyl)phenyl>-2,2-dimethylpropanamide 
• 3282-30-2 pivaloyl chloride 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 887144-94-7 Togni's reagent II 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 106-47-8 4-chloro-aniline 
• 445-03-4 4-chloro-2-(trifluoromethyl)aniline 

Downstream Products

• 1334531-18-8 (5-chloro-2-[(2,2-dimethylpropyl)amino]-3-methylphenyl)(2-methoxyphenyl)methanol 
• 1334531-19-9 methyl 4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methylphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoate 
• 1334531-20-2 4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methylphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoicacid 
• 1334531-21-3 ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-methylphenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate 
• 1334531-17-7 N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(trifluoromethyl)phenyl)-2,2-dimethylpropanamide 

Relevant articles and documents

Preparation method of ortho-amino trifluoroacetophenone and derivatives thereof

The invention relates to the field of organic synthesis, in particular to a preparation method of ortho-amino trifluoroacetophenone and derivatives thereof. The preparation of ortho-amino trifluoroacetophenone comprises three steps of amino protection, trifluoroacetylation and deprotection, the overall reaction condition is mild, the yield is high, and the method is suitable for large-scale production. In addition, on the basis of the preparation, substitution is carried out after amino diazotization, the ortho-amino trifluoroacetophenone derivative is further prepared, and the industrial application prospect is good.

CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group

The CuCl catalyzed direct trifluoromethylation of sp2 C-H bonds has been realized, using the Togni reagent as the CF3 source. This reaction achieves the goal of regio-selectively converting C-H into C-CF 3 with ecological and readily available starting materials.