88-17-5 Usage
Description
2-Aminobenzotrifluoride is a colorless liquid with a fishlike odor. It is insoluble in water and denser than water. Contact with it may irritate skin, eyes, and mucous membranes, and it may be toxic if ingested.
Uses
Used in Chemical Synthesis:
2-Aminobenzotrifluoride is used as a chemical intermediate for the synthesis of various organic compounds and pharmaceuticals. Its unique structure and reactivity make it a valuable building block in the development of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Aminobenzotrifluoride is used as a key component in the production of certain medications. Its properties allow for the creation of new drug candidates with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
2-Aminobenzotrifluoride is also utilized in the agrochemical industry for the development of new pesticides and herbicides. Its ability to form stable compounds with a wide range of biological targets makes it a valuable tool in the creation of more effective and environmentally friendly products.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2-Aminobenzotrifluoride is employed as a starting material for the synthesis of various dyes and pigments. Its unique chemical properties enable the production of vibrant and stable colorants for use in textiles, plastics, and other applications.
Used in Research and Development:
2-Aminobenzotrifluoride is used as a research compound in academic and industrial laboratories. Its unique properties and reactivity make it an interesting subject for studies aimed at understanding chemical reactions and developing new synthetic methods.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2-Aminobenzotrifluoride is a halogenated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Check Digit Verification of cas no
The CAS Registry Mumber 88-17-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 8 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88-17:
(4*8)+(3*8)+(2*1)+(1*7)=65
65 % 10 = 5
So 88-17-5 is a valid CAS Registry Number.
InChI:InChI=1/3CHF3O3S.Bi/c3*2-1(3,4)8(5,6)7;/h3*(H,5,6,7);/q;;;+3/p-3/rC3BiF9O9S3/c5-1(6,7)23(14,15)20-4(21-24(16,17)2(8,9)10)22-25(18,19)3(11,12)13
88-17-5Relevant articles and documents
Cross-Coupling through Ag(I)/Ag(III) Redox Manifold
Demonti, Luca,Mézailles, Nicolas,Nebra, Noel,Saffon-Merceron, Nathalie
supporting information, p. 15396 - 15405 (2021/10/12)
In ample variety of transformations, the presence of silver as an additive or co-catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross-coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e? redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through AgI/AgIII redox catalysis (i. e. CEL coupling), namely: i) easy AgI/AgIII 2e? oxidation mediated by air; ii) bpy/phen ligation to AgIII; iii) boron-to-AgIII aryl transfer; and iv) ulterior reductive elimination of benzotrifluorides from an [aryl-AgIII-CF3] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]+[AgIII(CF3)4]? (K-1), [(bpy)AgIII(CF3)3] (2) and [(phen)AgIII(CF3)3] (3), is described. The utility of 3 in cross-coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [AgIII(aryl)(CF3)3]? intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross-coupling by itself.
o-aminotrifluorotoluene synthesis method
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Paragraph 0006; 0013-0021, (2020/01/25)
The invention discloses an o-aminotrifluorotoluene synthesis method, wherein trifluorotoluene is used as a raw material, and a target compound is obtained through two-step reaction of nitration and reduction. Compared with the method in the prior art, the method of the invention has the following characteristics that trifluorotoluene is used as the raw material, so that the source is wide, and thepreparation is convenient; the nitration reaction is carried out at a normal pressure and a low temperature, so that the corrosion of the material to the pipeline and the equipment is small, and thenitration reaction is safe and reliable to the environment and operators; and the cheap nickel catalyst is used for replacing the common noble metal catalysts such as palladium, platinum and the like,so that the production cost is reduced, the methanol as the solvent is convenient to recover and can be recycled, and the emission of organic matters in the production process is reduced.
Visible-light-induced Pd-catalyzed: Ortho -trifluoromethylation of acetanilides with CF3SO2Na under ambient conditions in the absence of an external photocatalyst
Zou, Long,Li, Pinhua,Wang, Bin,Wang, Lei
supporting information, p. 3737 - 3740 (2019/04/01)
A visible-light-induced Pd-catalyzed ortho-trifluoromethylation of acetanilides with CF3SO2Na was developed. The reaction proceeded smoothly at room temperature in air without any external photocatalyst or additive, providing the desired products in moderate to good yields with good functional group tolerance and regioselectivity.