86802-68-8

Basic information

• Product Name: Benzenesulfonamide, N-[2-(trifluoromethyl)phenyl]-
• CAS NO: 86802-68-8
• Molecular Formula: C13H10F3NO2S
• Molecular Weight: 301.289
• Mol File: 86802-68-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[2-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[2-(trifluoromethyl)phenyl]-(86802-68-8)
• EPA Substance Registry System: Benzenesulfonamide, N-[2-(trifluoromethyl)phenyl]-(86802-68-8)

Safety Data

• Hazardous Substances Data: 86802-68-8(Hazardous Substances Data)

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 384-22-5 2-nitrobenzotrifluoride 
• 98-80-6 phenylboronic acid 

Downstream Products

• 221242-51-9 2-(2-trifluoromethyl-phenylsulfamoyl)-benzoic acid methyl ester 
• 221242-70-2 1,1-dioxo-4-(trifluoro-methanesulfonyloxy)-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid methyl ester 
• 221242-67-7 4-hydroxy-1,1-dioxo-2-(2-trifluoromethyl-phenyl)-1,2-dihydro-1λ6-benzo[e][1,2]thiazine-3-carboxylic acid methyl ester 
• 221242-55-3 2-[methoxycarbonylmethyl-(2-trifluoromethyl-phenyl)-sulfamoyl]-benzoic acid methyl ester 

Relevant articles and documents

Sequential C-S and S-N Coupling Approach to Sulfonamides

A one-pot three-component reaction involving nitroarenes, (hetero)arylboronic acids, and potassium pyrosulfite leading to sulfonamides was described. A broad range of sulfonamides bearing different reactive functional groups were obtained in good to excellent yields through sequential C-S and S-N coupling that does not require metal catalysts.

Development of a scalable process for CI-1034, an endothelin antagonist

A concise, convergent multikilogram synthesis of CI-1034 (1), a potent endothelin receptor antagonist, is described. A 15-step preparation from commercially available o-vanillin and benzenesulfonyl chloride employs a remarkably robust Suzuki coupling between a boronic acid and an aromatic sulfonate ester as the key synthetic step. A scalable route capable of producing multikilogram quantities of CI-1034 with no chromatographic steps is described in this contribution. Improvements to the process included using a 4-fluorobenzenesulfonate ester as a suitable substitute for the triflate group in the Suzuki reaction and the use of MgCl2 as a substitute for TiCl4 in a Dieckmann condensation to provide the benzothiazine dioxide core.

Preparation of Nonsymmetrical p-Benzoquinone Diimines for Evaluation as Protein Cleavage Reagents

In an effort to improve the yield, selectivity, and mildness of reaction conditions employed in protein cleavage with bisalkylating quinone diimines, a series of analogous reagents (1a-h) were prepared.These novel N1,N4 nonsymmetrica