1009-57-0

Basic information

• Product Name: 1-(5-amino-4-nitrothiophen-2-yl)ethanone
• CAS NO: 1009-57-0
• Molecular Formula: C₆H₆N₂O₃S
• Molecular Weight: 186.1884
• Mol File: 1009-57-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 387.9°C at 760 mmHg
• Flash Point: 188.4°C
• Density: 1.494g/cm³
• Vapor Pressure: 3.19E-06mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 1-(5-amino-4-nitrothiophen-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-amino-4-nitrothiophen-2-yl)ethanone(1009-57-0)
• EPA Substance Registry System: 1-(5-amino-4-nitrothiophen-2-yl)ethanone(1009-57-0)

Safety Data

• Hazardous Substances Data: 1009-57-0(Hazardous Substances Data)

Usage

General Description

1-(5-amino-4-nitrothiophen-2-yl)ethanone is a chemical compound with the molecular formula C6H6N2O3S. It consists of a thiophene ring with an amino group at the 5th carbon and a nitro group at the 4th carbon, along with a ketone group attached to the thiophene ring. This chemical is commonly used in organic synthesis and pharmaceutical research due to its potential applications as a building block for various compounds. It exhibits a range of properties and potential reactions due to the presence of the different functional groups, making it a versatile and valuable compound for use in the laboratory and industrial settings.

Upstream product

• 2160-55-6 1-(5-bromo-4-nitro-thiophen-2-yl)-ethanone 

Relevant articles and documents

Preparation of 2-halo-3-nitro-5-acyl thiophenes and intermediate compounds

Disclosed are novel intermediates and their preparation, and the preparation therefrom of 2-halo-3-nitro-5-acyl thiophenes which themselves are important intermediates for the preparation of azo dyes of the type, STR1 wherein C1 represents typically any aniline, tetrahydroquinoline, benzomorpholine or the like coupler and the acyl group contains from 1-10 carbons. It has been found that if 2-acyl thiophene is treated with a hydroxylamine compound, e.g., a salt of hydroxylamine, including sulphate, chloride or the like, to form the oxime prior to the 2-position halogenation and 3-position nitration steps, various side reactions such as halogenation of the acyl group and nitration of the 5-position are avoided, the yield of each step is improved, and the reactions are less sensitive to the deleterious effects of temperature variations and excess reactants. The oxime derivative is readily reconverted to the acyl derivative after the halogenation and nitration steps have been completed. This product is then readily aminated to give the 2-amino derivative.