100990-57-6

Basic information

• Product Name: Benzamide, N-[4-(1-methylethyl)phenyl]-
• Synonyms: N-(4-isopropylphenyl)benzamide;N-[4-(propan-2-yl)phenyl]benzamide;Benzamide, N-[4-(1-methylethyl)phenyl]-
• CAS NO: 100990-57-6
• Molecular Formula: C₁₆H₁₇NO
• Molecular Weight: 239.31
• Mol File: 100990-57-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzamide, N-[4-(1-methylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[4-(1-methylethyl)phenyl]-(100990-57-6)
• EPA Substance Registry System: Benzamide, N-[4-(1-methylethyl)phenyl]-(100990-57-6)

Safety Data

• Hazardous Substances Data: 100990-57-6(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 100-52-7 benzaldehyde 
• 98-82-8 Isopropylbenzene 
• 100-47-0 benzonitrile 
• 99-88-7 4-Isopropylaniline 
• 100-39-0 benzyl bromide 
• 93-55-0 1-phenyl-propan-1-one 
• 93-98-1 N-phenyl benzoyl amide 
• 134-81-6 benzil 
• 611-73-4 Benzoylformic acid 
• 861538-22-9 (4-isopropyl-phenyl)-methyl-carbamonitrile 
• 6950-79-4 para-isopropyl-N-methylaniline 
• 10026-13-8 phosphorus pentachloride 
• 861602-20-2 benzoic acid-(4-isopropyl-N-methyl-anilide) 

Downstream Products

• 100990-60-1 4-amino-4-isopropyl-2,5-cyclohexadienone 
• 99-88-7 4-Isopropylaniline 
• 65-85-0 benzoic acid 
• 187347-96-2 1-[N-(4-isopropylphenyl)benzimidoyl]-1H-benzotriazole 

Relevant articles and documents

Combination of the topliss approach with the Free-Wilson analysis in the study of antimycobacterial activity of 4-alkylthiobenzanilides

On the basis of a preliminary study of the antimycobacterial activity of thiobenzanilides, a group of 4′-isopropyl- and 4′-butylthiobenzanilides have been synthesized and tested against Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avi

Nickel/Briphos-Catalyzed Direct Transamidation of Unactivated Secondary Amides Using Trimethylsilyl Chloride

Direct transamidation of secondary amides was developed via nickel catalysis. In the presence of trimethylsilyl chloride and manganese, Ni(diglyme)Cl2 with a Briphos ligand efficiently promoted the transamidation of N-aryl benzamide derivatives with primary amines to afford the corresponding secondary amides in moderate to good yields. Primary amines bearing electron-donating groups gave higher yields of the transamidation products.

Copper-catalyzed aerobic oxidative C-C bond cleavage of simple ketones for the synthesis of amides

A Cu-catalyzed oxidative amidation of simple ketones with amines via carbon-carbon (C-C) bond cleavage has been developed. A number of aryl and alkyl ketones could be easily converted to amides using cheap copper salt as the catalyst and O2 as the oxidant with a wide range of amines, including primary and secondary amines. This method shows a notable advantage of the broad scope for the substrate, thus providing a practical approach to amides. A plausible mechanism is proposed based on the preliminary experiments.

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C-N Cleavage of N, N-Dibenzylanilines

A visible-light-driven photoredox-catalyzed nonaqueous oxidative C-N cleavage of N,N-dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2-(dibenzylamino)benzamide to afford quinazolinones with (NH4)2S2O8 as an additive. Mechanistic studies imply that the reaction might undergo in situ generation of α-amino radical to imine by C-N bond cleavage followed by the addition of superoxide ion to form amides.