101089-40-1Relevant articles and documents
Formal synthesis of salinosporamide A via NHC-catalyzed intramolecular lactonization
Struble, Justin R.,Bode, Jeffrey W.
experimental part, p. 4957 - 4967 (2009/11/30)
An N-heterocyclic carbene (NHC) catalyzed intramolecular lactonization to prepare densely functionalized bicyclic γ-lactam-γ-lactone adducts from enals is reported. This method has been applied to the formal synthesis of salinosporamide A, a potent 20S pr