101125-34-2 Usage
Description
3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOLE-2-CARBALDEHYDE is a chemical compound that serves as an intermediate in the synthesis of Fluvastatin, a medication used to treat high cholesterol and cardiovascular diseases. It is a white solid with specific chemical properties that make it a valuable component in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOLE-2-CARBALDEHYDE is used as an intermediate for the synthesis of Fluvastatin (F601250), a cholesterol-lowering drug. Its role in the production process is crucial for creating an effective medication that helps manage high cholesterol levels and reduces the risk of cardiovascular events.
Used in Quality Control:
1-Isopropyl-3-(4-fluorophenyl)indole-2-carboxaldehyde (Fluvastatin EP Impurity G) is used as an impurity reference material in the quality control of Fluvastatin. This application ensures the purity and safety of the final drug product by providing a reference point for identifying and quantifying impurities during the manufacturing process.
Check Digit Verification of cas no
The CAS Registry Mumber 101125-34-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,1,2 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 101125-34:
(8*1)+(7*0)+(6*1)+(5*1)+(4*2)+(3*5)+(2*3)+(1*4)=52
52 % 10 = 2
So 101125-34-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H16FNO/c1-12(2)20-16-6-4-3-5-15(16)18(17(20)11-21)13-7-9-14(19)10-8-13/h3-12H,1-2H3
101125-34-2Relevant articles and documents
Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations
Niwa, Takashi,Ochiai, Hidenori,Watanabe, Yasuyoshi,Hosoya, Takamitsu
supporting information, p. 14313 - 14318 (2015/11/27)
Ni/Cu-catalyzed transformation of fluoroarenes to arylboronic acid pinacol esters via C-F bond cleavage has been achieved. Further versatile derivatization of an arylboronic ester has allowed for the facile two-step conversion of a fluoroarene to diverse functionalized arenes, demonstrating the synthetic utility of the method.
Cat-1 inhibitors, pharmaceutical compositions and methods of use
-
, (2008/06/13)
The invention relates to compounds of the formula STR1 wherein R1, R2, R2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, diastereomers or mixtures thereof or geometric isomer or mixtures thereof, and pharmaceutically acceptable salts thereof. The compounds of formula I inhibit enzyme carnitine acyltransferase 1 (CAT-1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction.
2-FORMYLATION OF 3-ARYLINDOLES
Walkup, R. E.,Linder, J.
, p. 2155 - 2158 (2007/10/02)
The preparation of N-substituted-3-(4-fluorophenyl)indoles (R = H, CH3, i-Pr) and their direct formylation at the 2-position by Vilsmeier-Haack or Friedel-Crafts methodologies is described.
