500731-91-9

Basic information

• Product Name: (4R,6S)-6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
• Synonyms: (3R,5S)-Fluvastatin-3,5-acetonide tert-Butyl Ester;(4R,6S)-6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
• CAS NO: 500731-91-9
• Molecular Formula: C₃₁H₃₈FNO₄
• Molecular Weight: 507.64
• Product Categories: Aromatics;Chiral Reagents;Heterocycles
• Mol File: 500731-91-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 608.734°C at 760 mmHg
• Flash Point: 321.951°C
• Appearance: /
• Density: 1.123g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: Refrigerator
• Solubility: Acetone, Diethyl Ether, Ethyl Acetate
• CAS DataBase Reference: (4R,6S)-6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,6S)-6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester(500731-91-9)
• EPA Substance Registry System: (4R,6S)-6-[(1E)-2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester(500731-91-9)

Safety Data

• Hazardous Substances Data: 500731-91-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

An intermediate for the preparation of (3R,5S)-Fluvastatin.

InChI:InChI=1/C31H38FNO4/c1-20(2)33-26-11-9-8-10-25(26)29(21-12-14-22(32)15-13-21)27(33)17-16-23-18-24(36-31(6,7)35-23)19-28(34)37-30(3,4)5/h8-17,20,23-24H,18-19H2,1-7H3/b17-16+/t23-,24-/m1/s1

Upstream product

• 956034-97-2 2-bromomethyl-3-(4-fluorophenyl)-1-isopropylindole 
• 101125-34-2 3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-carboxaldehyde 
• 124655-09-0 1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate 
• 124752-23-4 tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate 
• 93957-49-4 3-(4'-fluorophenyl)-1-(1'-methylethyl)-1H-indole 

Relevant articles and documents

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

Ni/Cu-catalyzed transformation of fluoroarenes to arylboronic acid pinacol esters via C-F bond cleavage has been achieved. Further versatile derivatization of an arylboronic ester has allowed for the facile two-step conversion of a fluoroarene to diverse functionalized arenes, demonstrating the synthetic utility of the method.