1011717-00-2

Basic information

• Product Name: Benzoic acid, 4-(4-chloro-7H-pyrrolo[2,3-d]pyriMidin-6-yl)-, Methyl ester
• Synonyms: Benzoic acid, 4-(4-chloro-7H-pyrrolo[2,3-d]pyriMidin-6-yl)-, Methyl ester;Methyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate
• CAS NO: 1011717-00-2
• Molecular Formula: C₁₄H₁₀ClN₃O₂
• Molecular Weight: 287.7011
• Mol File: 1011717-00-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.414±0.06 g/cm3(Predicted)
• PKA: 10.34±0.50(Predicted)
• CAS DataBase Reference: Benzoic acid, 4-(4-chloro-7H-pyrrolo[2,3-d]pyriMidin-6-yl)-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(4-chloro-7H-pyrrolo[2,3-d]pyriMidin-6-yl)-, Methyl ester(1011717-00-2)
• EPA Substance Registry System: Benzoic acid, 4-(4-chloro-7H-pyrrolo[2,3-d]pyriMidin-6-yl)-, Methyl ester(1011717-00-2)

Safety Data

• Hazardous Substances Data: 1011717-00-2(Hazardous Substances Data)

Upstream product

• 3609-53-8 methyl 4-acetylbenzoate 
• 171364-80-0 methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 56893-25-5 methyl 4-(2-bromoacetyl)benzoate 
• 1011716-95-2 ethyl 2-amino-5-(4-(methoxycarbonyl)phenyl)-1H-pyrrole-3-carboxylate 
• 1011716-97-4 methyl 4-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate 

Downstream Products

• 1011717-01-3 methyl 4-(4-((R)-1-phenylethylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoate 
• 863307-00-0 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)benzoic acid 
• 863307-01-1 [4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-(4-methylpiperazin-1-yl)methanone 

Relevant articles and documents

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

BICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to a class of substituted bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts and pharmaceutical compositions

FUSED BICYCLIC PYRIMIDINES AS PTK INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to fused bicyclic pyrimidine containing zinc- binding moiety based derivatives that have unique properties as protein tyrosine kinase (PTK) inhibitors and their use in the treatment of PTK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.