1012058-78-4 Usage
Description
Sorafenib related compound 10, also known as Sorafenib Hydroxydemethylamine, is a derivative of Sorafenib (S676850), a multiple kinase inhibitor that targets both RAF kinase and receptor tyrosine kinases involved in angiogenesis. It is an antineoplastic agent with potential applications in cancer treatment.
Uses
Used in Oncology:
Sorafenib related compound 10 is used as an antineoplastic agent for its potential role in cancer treatment. It targets multiple kinases that promote angiogenesis, making it a promising candidate for the development of targeted therapies against various types of cancer.
Used in Drug Development:
Sorafenib related compound 10 is used in drug development as a lead compound for the synthesis of novel kinase inhibitors. Its structure and activity can be further optimized to improve its potency, selectivity, and pharmacokinetic properties, leading to the discovery of more effective and safer anticancer drugs.
Used in Research:
Sorafenib related compound 10 is used in research as a tool compound to study the role of RAF kinase and receptor tyrosine kinases in cancer progression and angiogenesis. It can help researchers understand the molecular mechanisms underlying these processes and identify potential therapeutic targets for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 1012058-78-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,2,0,5 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1012058-78:
(9*1)+(8*0)+(7*1)+(6*2)+(5*0)+(4*5)+(3*8)+(2*7)+(1*8)=94
94 % 10 = 4
So 1012058-78-4 is a valid CAS Registry Number.
1012058-78-4Relevant articles and documents
Preparation method and application of sorafenib photoaffinity probe molecule based on halogen intermediate
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Paragraph 0025; 0028, (2021/07/09)
The invention discloses a preparation method and application of a sorafenib photoaffinity probe molecule based on a halogen intermediate, and relates to the technical field of biological medicines. The preparation method of the sorafenib photoaffinity pro
PREPARATION AND USE OF MOLECULAR SITE TARGETED AND ACTIVATED KINASE INHIBITOR
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, (2019/12/12)
Disclosed are molecularly targeted and activated kinase inhibitors and use thereof. Specifically, a compound represented by the following formula A or a pharmaceutically acceptable salt thereof, wherein X is a polar and a non-polar uncharged amino acid such as alanine, proline or threonine; A is alanine; N is asparagine; PABC is -NH-phenyl-CH2-O-; and Z is a drug molecule; wherein the lactobionic acid residue, XAN and PABC are linked to each other by an amide bond; PABC is bonded to Z by an ester group, i.e., -OC(O)-. ????????Lacto-XAN-PABC-Z?????(Formula A)
RAF-DEGRADING CONJUGATE COMPOUNDS
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Paragraph 0209; 0216, (2018/11/22)
The present disclosure provides, inter alia, RAF-Degrading Conjugate Compounds that are useful in the treatment of cancer and other RAF related diseases. Also provided are, pharmaceutical compositions, methods of treatment, and kits comprising a RAF- Degrading Conjugate Compound.
