1015076-81-9

Basic information

• Product Name: (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate
• Synonyms: (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate
• CAS NO: 1015076-81-9
• Molecular Weight: 427.316
• Mol File: 1015076-81-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate(1015076-81-9)
• EPA Substance Registry System: (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate(1015076-81-9)

Safety Data

• Hazardous Substances Data: 1015076-81-9(Hazardous Substances Data)

Upstream product

• 165896-48-0 2-[3-(3-bromo-phenyl)-3-oxo-propyl]-benzoic acid methyl ester 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1015076-82-0 (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid 
• 1045844-73-2 methyl 2-[3-(R)-acetylsulfanyl-3-(3-bromophenyl)-propyl]-benzoate 

Relevant articles and documents

Synthesis method of montelukast sodium

The invention provides a montelukast sodium synthesis method, which comprises: (1) carrying out asymmetric reduction on a compound represented by a formula (VII) to obtain a compound represented by aformula (VI); (2) reacting the compound in the formula (VI) with methylsulfonyl chloride to obtain an intermediate compound in a formula (V), and directly performing substitution reaction on the intermediate and 1-mercaptomethyl cyclopropyl acetic acid without separation to obtain a compound in a formula (III); (3) carrying out Heck coupling reaction on the compound shown as the formula (III) anda compound shown as a formula (IV) under the action of a palladium catalyst to obtain a compound shown as a formula (II); and (4) carrying out direct addition reaction on the compound shown in the formula (II) and a methyl Grignard reagent to obtain montelukast sodium. The synthesis method is short in step, mild in condition, simple and convenient to operate, beneficial to reducing the process cost and capable of realizing industrial production.

PROCESS FOR OBTAINING MONTELUKAST

The present invention refers to a process for the synthesis of (1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid or its salts, comprising the reaction between 7-Chloro-2-vinyl-quinoline and a compound of formula (I) wherein X is a halogen atom or a group of formula —OSO2R, wherein R is selected from the group consisting of CF3, tolyl, methyl and F; in the presence of a palladium based catalyst. The invention is also directed to intermediates compounds of the process.