1015076-82-0

Basic information

• Product Name: (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid
• Synonyms: (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid
• CAS NO: 1015076-82-0
• Molecular Weight: 477.419
• Mol File: 1015076-82-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid(1015076-82-0)
• EPA Substance Registry System: (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid(1015076-82-0)

Safety Data

• Hazardous Substances Data: 1015076-82-0(Hazardous Substances Data)

Upstream product

• 1015076-81-9 (S)-methyl 2-(3-(3-bromophenyl)-3-methylsulfonyloxypropyl)benzoate 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 
• 165896-48-0 2-[3-(3-bromo-phenyl)-3-oxo-propyl]-benzoic acid methyl ester 
• 1021952-71-5 (S)-2-(2-(3-(3-bromophenyl)-3-chloropropyl)phenyl)propan-2-ol 
• 1045844-78-7 methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate 

Downstream Products

• 1015076-80-8 (1-{1-(R)-(3-bromophenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid 
• 1021952-72-6 (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid dicyclohexylamine salt 

Relevant articles and documents

Synthesis method of montelukast sodium

The invention provides a montelukast sodium synthesis method, which comprises: (1) carrying out asymmetric reduction on a compound represented by a formula (VII) to obtain a compound represented by aformula (VI); (2) reacting the compound in the formula (VI) with methylsulfonyl chloride to obtain an intermediate compound in a formula (V), and directly performing substitution reaction on the intermediate and 1-mercaptomethyl cyclopropyl acetic acid without separation to obtain a compound in a formula (III); (3) carrying out Heck coupling reaction on the compound shown as the formula (III) anda compound shown as a formula (IV) under the action of a palladium catalyst to obtain a compound shown as a formula (II); and (4) carrying out direct addition reaction on the compound shown in the formula (II) and a methyl Grignard reagent to obtain montelukast sodium. The synthesis method is short in step, mild in condition, simple and convenient to operate, beneficial to reducing the process cost and capable of realizing industrial production.

A NEW PROCESS FOR THE PREPARATION OF MONTELUKAST

The present invention describes a novel process for the preparation of montelukast acid, and its pharmaceutically acceptable salts and esters.