1045844-78-7

Basic information

• Product Name: methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate
• Synonyms: methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate
• CAS NO: 1045844-78-7
• Molecular Weight: 491.446
• Mol File: 1045844-78-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate(1045844-78-7)
• EPA Substance Registry System: methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate(1045844-78-7)

Safety Data

• Hazardous Substances Data: 1045844-78-7(Hazardous Substances Data)

Upstream product

• 855473-50-6 1-bromomethylcyclopropyl acetic acid methyl ester 
• 1045844-76-5 Methyl 2-[3-(R)-(3-bromophenyl)-3-mercaptopropyl]-benzoate 

Downstream Products

• 1015076-82-0 (R)-2-(1-((1-(3-bromophenyl)-3-(2-(methoxycarbonyl)phenyl)propylthio)methyl)cyclopropyl)acetic acid 

Relevant articles and documents

PROCESS FOR OBTAINING MONTELUKAST

The present invention refers to a process for the synthesis of (1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid or its salts, comprising the reaction between 7-Chloro-2-vinyl-quinoline and a compound of formula (I) wherein X is a halogen atom or a group of formula —OSO2R, wherein R is selected from the group consisting of CF3, tolyl, methyl and F; in the presence of a palladium based catalyst. The invention is also directed to intermediates compounds of the process.