855473-50-6

Basic information

• Product Name: Methyl 2-(1-(broMoMethyl)cyclopropyl) acetate
• Synonyms: Methyl 2-(1-(broMoMethyl)cyclopropyl) acetate;2-(1-Bromomethylcyclopropyl)acetic acid methyl ester;(1-Bromomethyl-cyclopropyl)-acetic acid methyl ester
• CAS NO: 855473-50-6
• Molecular Formula: C₇H₁₁BrO₂
• Molecular Weight: 207.06504
• EINECS: 1308068-626-2
• Mol File: 855473-50-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 211℃
• Flash Point: 103℃
• Appearance: /
• Density: 1.443
• CAS DataBase Reference: Methyl 2-(1-(broMoMethyl)cyclopropyl) acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(1-(broMoMethyl)cyclopropyl) acetate(855473-50-6)
• EPA Substance Registry System: Methyl 2-(1-(broMoMethyl)cyclopropyl) acetate(855473-50-6)

Safety Data

• Hazardous Substances Data: 855473-50-6(Hazardous Substances Data)

Usage

Uses

Methyl 2-(1-Bromomethylcyclopropyl)acetate is a reactant in organic synthesis.

Upstream product

• 142148-13-8 1-hydroxymethylcyclopropylacetic acid methyl ester 
• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 

Downstream Products

• 152922-71-9 1-(hydroxymethyl)cyclopropaneacetonitrile 
• 338392-48-6 2-(1-(bromomethyl)cyclopropyl)acetonitrile 
• 162515-68-6 1-(sulfanylmethyl)cyclopropaneacetic acid 
• 855473-51-7 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester 
• 158966-92-8 montelukast 
• 1399184-58-7 (1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid diisobutylamine salt 
• 151767-02-1 Montelukast sodium 
• 1045844-78-7 methyl 2-[3-(R)-(3-bromophenyl)-3-(1-methoxycarbonylmethyl-cyclopropylmethylsulfanyl)-propyl]-benzoate 
• 937275-23-5 [R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]phenyl]-3-[2-(methylcarbonyl)phenyl] propyl]thio]methyl]cyclopropane acetic acid 

Relevant articles and documents

Montelukast side chain intermediate and preparing method thereof

The invention belongs to the field of medical chemistry, and particularly relates to a montelukast side chain intermediate and a preparing method thereof. A provided intermediate compound is 6-halogenated methyl-5,7-dioxaspiro[2,5] octane, wherein 1,1-cyclopropyl dimethyl carbinol serving as a starting material and 2-halogeno-1,1-dimethoxyethane are subjected to a transacetalation reaction under solid acid catalysis to obtain 6-halogenated methyl-5,7-dioxaspiro[2,5] octane, the intermediate is treated with organic alkali and then hydrolyzed with a water solution containing acetic acid to obtain monoacetylated protected diol. The problems that monoacetylated protected diol is poor in selectivity, and diol loss is serious are solved, the availability of the raw materials is improved, and the montelukast side chain intermediate can be synthesized economically and conveniently.