101569-81-7

Basic information

• Product Name: 4-hydroxy-3-[1-(phenylhydrazono)ethyl]-quinolin-2(1H)-one
• Synonyms: 4-hydroxy-3-[1-(phenylhydrazono)ethyl]-quinolin-2(1H)-one
• CAS NO: 101569-81-7
• Molecular Weight: 293.325
• Mol File: 101569-81-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-3-[1-(phenylhydrazono)ethyl]-quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-[1-(phenylhydrazono)ethyl]-quinolin-2(1H)-one(101569-81-7)
• EPA Substance Registry System: 4-hydroxy-3-[1-(phenylhydrazono)ethyl]-quinolin-2(1H)-one(101569-81-7)

Safety Data

• Hazardous Substances Data: 101569-81-7(Hazardous Substances Data)

Upstream product

• 26138-64-7 4-hydroxy-3-acetyl-1H-quinoline-2-one 
• 100-63-0 phenylhydrazine 
• 70254-43-2 4-Hydroxy-2-quinolone 

Downstream Products

• 97789-05-4 1-phenyl-3-methyl-4,5-dihydro-1H-pyrazolo<4,5-c>quinolin-4-one 

Relevant articles and documents

Synthesis, crystal structure and spectroscopic studies of 3- hydrazono- and 3-hydroxyiminoquinolin-2-ones

3-(Hydrazonoethyl)quinolinones 6-11, 13 and 3- (hydroxyiminoethyl)quinolinones 14, 15 are prepared by a condensation reaction of 3-acetylquinolinones 4, 5 with a variety of 1,2-(bis)nucleophiles. The structures of the isolated compounds have been elucidated using 1H and 13C nmr spectroscopy. X-ray diffraction studies of compound 14 were also performed.

Ring closure reactions of 3-arylhydrazonoalkyl-quinolin-2-ones to 1-aryl-pyrazolo[4,3-c]quinolin-2-ones

4-Hydroxy-3-arylhydrazonoalkyl-2-quinolones 6 or reactive derivatives such as 3-arylhydrazonoalkyl-4-tosyloxy-2-quinolones 7 or 4-chloro-3- arylhydrazonoalkyl-2-quinolones 14, which are obtained via 3-acyl-4- hydroxyquinolones 4, 10 or 3-phenylaminomethylene-quinoline-2,4-diones 12, cyclize in excellent yields to 1-aryl-pyrazolo[4,3-c]quinolin-4-ones (11). The cyclization conditions were investigated by differential scanning calorimetry (DSC).