1016225-28-7

Basic information

• Product Name: (E)-6-phenyl-3-hexenoic acid
• Synonyms: (E)-6-phenyl-3-hexenoic acid
• CAS NO: 1016225-28-7
• Molecular Weight: 190.242
• Mol File: 1016225-28-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (E)-6-phenyl-3-hexenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-6-phenyl-3-hexenoic acid(1016225-28-7)
• EPA Substance Registry System: (E)-6-phenyl-3-hexenoic acid(1016225-28-7)

Safety Data

• Hazardous Substances Data: 1016225-28-7(Hazardous Substances Data)

Upstream product

• 141-82-2 malonic acid 
• 18328-11-5 3-benzyl propionaldehyde 
• 124-38-9 carbon dioxide 
• 99902-35-9 5-phenylpent-1-yn-3-ol 
• 16900-77-9 5-phenyl-2-pentynol 
• 64-18-6 formic acid 
• 37904-38-4 5-phenylpent-1-en-3-ol 
• 16520-62-0 4-Phenyl-1-butyne 
• 75553-23-0 (E)-5-phenyl-2-penten-1-ol 
• 55282-95-6 ethyl (2E)-5-phenylpent-2-enoate 
• 104-53-0 3-phenyl-propionaldehyde 
• 2046-17-5 methyl 3-(benzyl)propanoate 
• 1821-12-1 4-Phenylbutyric acid 
• 103240-88-6 5-phenylpenten-3-yl acetate 

Downstream Products

• 1016225-10-7 (E)-6-phenyl-3-hexenoic acid phenyl amide 
• 67280-87-9 (E)-6-(phenyl)hex-3-en-1-ol 
• 1316253-58-3 3-(tert-butyldimethylsiloxy)-6-phenylhexanal 
• 1316253-60-7 3-(tert-butyldimethylsiloxy)-6-phenylhexanoic acid phenyl ketone 
• 1316253-74-3 3-(tert-butyldimethylsiloxy)-6-phenylhexanoic acid N,N-methoxymethylamide 
• 1316253-55-0 3-hydroxy-6-phenylhexanoic acid N,N-methoxymethylamide 

Relevant articles and documents

Method for regio- and stereoselective synthesis of (E)-Β,γ- unsaturated acids from aldehydes under solvent-free conditions

Synthesis of (E)-β,-γunsaturated acids from aldehydes with malonic acid has been explored under solvent-free conditions. The modified Knoevenagel condensation reaction with N-methyl morpholine (NMM) as catalyst exhibits highly β,-γ regioselectivity and exclusively E-stereoselectivity. A mechanism accounting for both regio- and stereoselectivity has been proposed and preliminarily studied. Copyright Taylor & Francis Group, LLC.

Palladium-Catalyzed Amide-Directed Enantioselective Hydrocarbofunctionalization of Unactivated Alkenes Using a Chiral Monodentate Oxazoline Ligand

A Pd-catalyzed amide-directed enantioselective hydrocarbofunctionalization of unactivated alkenes with C-H nucleophiles has been developed using a chiral monodentate oxazoline (MOXin) ligand. Various indoles react at C3 position with aminoquinoline-coupled 3-alkenamides to give γ addition products in good to excellent yield and enantioselectivity. This study represents an important advance of the development of chiral monodentate oxazoline ligands, which have been underexplored for asymmetric catalysis.

Efficient Pd-Catalyzed Regio- and Stereoselective Carboxylation of Allylic Alcohols with Formic Acid

Formic acid is efficiently used as a C1 source to directly carboxylate allylic alcohols in the presence of a low loading of palladium catalyst and acetic anhydride as additive to afford β,γ-unsaturated carboxylic acids with excellent chemo-, regio-, and stereoselectivity. The reaction proceeds through a carbonylation process with in situ-generated carbon monoxide under mild conditions, avoiding the use of high-pressure gaseous CO. A bisphosphine ligand with a large bite angle (4,5-bis{diphenylphosphino}-9,9-dimethylxanthene, Xantphos) was found to be uniquely effective for this transformation. The regio- and stereoconvergence of this reaction is ascribed to the thermodynamically favored isomerization of the allylic electrophile in the presence of the palladium catalyst.