101772-29-6

Basic information

• Product Name: BOC-N-ME-SER-OH
• Synonyms: BOC-MESER-OH;BOC-N-METHYL-L-SERINE;BOC-N-ME-SERINE;BOC-N-ME-SER-OH;BOC-L-MESER-OH;N-ALPHA-(T-BUTYLOXYCARBONYL)-N-ALPHA-METHYL-L-SERINE;N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-SERINE;N-(tert-Butoxycarbonyl)-N-methyl-L-serine
• CAS NO: 101772-29-6
• Molecular Formula: C9H17NO5
• Molecular Weight: 219.23
• EINECS: 1533716-785-6
• Product Categories: N-Methyl Amino Acids;amino acids
• Mol File: 101772-29-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 83-87 °C
• Boiling Point: 353.2 °C at 760 mmHg
• Flash Point: 167.4 °C
• Appearance: /Solid
• Density: 1.215 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.63±0.10(Predicted)
• BRN: 8685334
• CAS DataBase Reference: BOC-N-ME-SER-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-N-ME-SER-OH(101772-29-6)
• EPA Substance Registry System: BOC-N-ME-SER-OH(101772-29-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 101772-29-6(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

Uses

Different sources of media describe the Uses of 101772-29-6 differently. You can refer to the following data:
1. N-Boc-N-methyl-L-serine is used as a precursor in organic synthesis and pharmaceuticals.
2. Boc-N-Me-Ser-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 74-88-4 methyl iodide 

Downstream Products

• 397243-76-4 2-(tert-butoxycarbonyl-methyl-amino)-3-(4-phenoxy-benzenesulfonyl)-propionic acid methyl ester 

Relevant articles and documents

Design, synthesis, and in vitro antiplasmodial activity of 4-aminoquinolines containing modified amino acid conjugates

Abstract: A new series of side chain-modified 4-aminoquinolines were synthesized and screened for in vitro antiplasmodial activity against both chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. Among the series, compounds 30 and 31 showed significant inhibition of parasite growth against K1 strain of P. falciparum with IC50 values 0.28 and 0.31?μM, respectively, whereas compounds 34, 35, and 38 exhibited superior activity against K1 strain with IC50 values 0.18, 0.22, and 0.17?μM, respectively, as compared to 0.255?μM for chloroquine (CQ). All the compounds displayed good resistance factor between 1.54 and >34.48 as against 51.0 for CQ. All these analogues were found to form strong complex with hematin and inhibited the β-hematin formation in vitro, suggesting that this class of compounds act on a heme polymerization target. Overall results suggest that present series of compounds appear to be promising for further lead optimization to obtain compounds active against drug-resistant parasites. Graphical Abstract: [Figure not available: see fulltext.]